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Figure 3 | Journal of Experimental & Clinical Cancer Research

Figure 3

From: Lysosomal Membrane Permeabilization is an Early Event in Sigma-2 Receptor Ligand Mediated Cell Death in Pancreatic Cancer

Figure 3

Sigma-2 receptor ligands localize to lysosomes and induce lysosomal membrane permeabilization. Upper two rows, confocal images of SW120 and PB385 (100 nM) in Bxpc3 cells, left (green), LysoTracker Red (25 nM), middle (red), and overlay right. Bottom row, acridine orange (2 μg/mL) staining for lysosomal integrity in Bxpc3 cells treated with vehicle, left, PB282 (30 μM) middle, or SW43 (30 μM) right for one hour. Scale bar = 20 μm.

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