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Figure 6 | Journal of Experimental & Clinical Cancer Research

Figure 6

From: Over-expression of BMPR-IB reduces the malignancy of glioblastoma cells by upregulation of p21 and p27Kip1

Figure 6

Overexpression of BMPR-IB in human glioma cells decreased tumorigenicity in vivo. (A) Tumor growth in the subcutis of nude mice. (B) Representative H&E staining and immunohistochemistry of tumors derived from intracranial xenografts of glioma cells.aL-dL(low magnification images)L and a-d(high magnification images), HE staining of tumors derived from intracranial xenografts of glioma cells. e-h, GFAP immunohistocheistry of tumors derived from intracranial xenografts of glioma cells. i-l, CD34 immunohistocheistry of tumors derived from intracranial xenografts of glioma cells. (a, e, i, U251-AAV. b, f, j, U251-AAV-IB. c, g, k, SF763-si-control. d, h, l, SF763-si-IB). Magnification was Ɨ20 in a-d, and Ɨ40 in e-l. (C) Survival of animals intracranially injected with glioma cells that were infected or knocked down using BMPR-IB and control vectors (log rank test: pā€‰<ā€‰0.0001).

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