Table 5 Deregulated miRNAs ( n = 19) consistently reported in profiling studies (lung SCC tissue versus normal)
Direction of expression | miRNA namea | No. of studies with same direction (reference) | Total number of tissue samples tested | Subset of studies with fold change | |||
|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | No. of studies | Total number of tissue samples tested | Mean fold change | Range |
Up-regulated | miR-210 | 4 (24,26,29,30) | 247 | 1 | 30 | 2.37 | - |
| Â | miR-203 | 3 (24,26,30) | 217 | 0 | - | - | - |
| Â | miR-205 | 3 (26,29,30) | 176 | 1 | 30 | 2.99 | - |
| Â | miR-21 | 3 (29,30,33) | 116 | 2 | 38 | 2.53 | 1.74 - 3.31 |
| Â | miR-31 | 3 (26,29,33) | 106 | 2 | 38 | 4.42 | 1.58 - 7.26 |
| Â | miR-182 | 2 (24,26) | 139 | 0 | - | - | - |
| Â | miR-200c | 2 (24,29) | 101 | 1 | 30 | 1.66 | - |
| Â | miR-18a | 2 (26,33) | 76 | 1 | 8 | 2.24 | - |
Down-regulated | miR-126 | 4 (26,29,31,33) | 112 | 3 | 44 | 0.18 | 0.00 - 0.42 |
| Â | miR-30a | 4 (26,29,31,33) | 112 | 3 | 44 | 0.28 | 0.11 - 0.53 |
| Â | miR-30d | 3 (29,31,33) | 44 | 3 | 44 | 0.33 | 0.22 - 0.54 |
| Â | miR-195 | 2 (26,29) | 98 | 1 | 30 | 0.53 | - |
| Â | miR-497 | 2 (26,29) | 98 | 1 | 30 | 0.66 | - |
| Â | miR-126* | 2 (30,33) | 86 | 1 | 8 | 0.16 | - |
| Â | miR-143 | 2 (30,33) | 86 | 1 | 8 | 0.24 | - |
| Â | miR-145 | 2 (26,33) | 76 | 1 | 8 | 0.48 | - |
| Â | miR-451 | 2 (29,33) | 38 | 2 | 38 | 0.37 | 0.22 - 0.53 |
| Â | miR-30b | 2 (29,33) | 38 | 2 | 38 | 0.50 | 0.48 - 0.53 |
| Â | miR-101 | 2 (31,33) | 14 | 2 | 14 | 0.34 | 0.29 - 0.39 |