Figure 1
From: Potential utility of eGFP-expressing NOG mice (NOG-EGFP) as a high purity cancer sampling system
Confirmation of eGFP expression in NOG-EGFP mice. A) NOG-EGFP mice were fluorescently visualized under a hand-held UV lamp. B) Representative photos of internal organs of NOG-EGFP mice. The fluorescence was detected in all internal organs with IVIS® spectrum system. C) Skin fibroblasts of NOG-EGFP mice cultured on the dishes were fluorescent under the fluorescence microscope. D) Histology of patients-derived pancreatic cancer xenografts in NOG-EGFP mice. D-a) H&E staining. D-b) immunohistochemistry of the anti-eGFP antibody. eGFP-expressing cells are seen in the stroma. D-c) eGFP positive cells visualized under the fluorescence microscope are seen in the stroma, concordant with of Figure 1Db.