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Table 1 125I-irradiation induced genes associated with apoptosis and cell cycle arrest

From: 125I seed irradiation induces up-regulation of the genes associated with apoptosis and cell cycle arrest and inhibits growth of gastric cancer xenografts

GENE_NAME

DESCRIPTION

Fold change

P value

FDR

Pro-apoptotic genes

BNIP3

BCL2/adenovirus E1B 19 kDa interacting protein 3

2.1

0.045

0.050

MAPK8

mitogen-activated protein kinase 8

1.7

0.017

0.047

BCL2L11

BCL2-like 11 (apoptosis facilitator)

1.9

5.39E-04

0.036

AKT1

v-akt murine thymoma viral oncogene homolog 1

1.4

0.028

0.049

BMF

Bcl2 modifying factor

1.5

0.005

0.040

P2RX7

purinergic receptor P2X, ligand-gated ion channel, 7

1.4

0.004

0.040

TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

1.4

0.003

0.038

APH1A

anterior pharynx defective 1 homolog A (C. elegans)

1.4

0.010

0.039

TRAIP

TRAF interacting protein

1.4

0.032

0.046

JAK2

Janus kinase 2 (a protein tyrosine kinase)

1.6

0.011

0.045

TRIM35

tripartite motif-containing 35

1.3

0.018

0.046

ITSN1

intersectin 1 (SH3 domain protein)

1.5

0.020

0.046

TAP2

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

1.3

0.024

0.048

ACVR1B

activin A receptor, type IB

1.6

0.009

0.046

Genes associated with cell cycle arrest

CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

1.3

0.034

0.049

RFWD3

ring finger and WD repeat domain 3

1.3

0.040

0.050

HUS1

HUS1 checkpoint homolog (S. pombe)

1.4

0.017

0.047

PMP22

peripheral myelin protein 22

1.5

0.042

0.050

CDC25C

cell division cycle 25 C

1.5

0.017

0.047

WNT9A

wingless-type MMTV integration site family, member 9A

1.6

0.048

0.050

CCNG2

cyclin G2

1.5

0.003

0.038

CDC7

CDC7 cell division cycle 7 (S. cerevisiae)

1.4

0.016

0.049

C12orf32

chromosome 12 open reading frame 32

1.5

0.002

0.033