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Table 1 125I-irradiation induced genes associated with apoptosis and cell cycle arrest

From: 125I seed irradiation induces up-regulation of the genes associated with apoptosis and cell cycle arrest and inhibits growth of gastric cancer xenografts

GENE_NAME DESCRIPTION Fold change P value FDR
Pro-apoptotic genes
BNIP3 BCL2/adenovirus E1B 19 kDa interacting protein 3 2.1 0.045 0.050
MAPK8 mitogen-activated protein kinase 8 1.7 0.017 0.047
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.9 5.39E-04 0.036
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.4 0.028 0.049
BMF Bcl2 modifying factor 1.5 0.005 0.040
P2RX7 purinergic receptor P2X, ligand-gated ion channel, 7 1.4 0.004 0.040
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.4 0.003 0.038
APH1A anterior pharynx defective 1 homolog A (C. elegans) 1.4 0.010 0.039
TRAIP TRAF interacting protein 1.4 0.032 0.046
JAK2 Janus kinase 2 (a protein tyrosine kinase) 1.6 0.011 0.045
TRIM35 tripartite motif-containing 35 1.3 0.018 0.046
ITSN1 intersectin 1 (SH3 domain protein) 1.5 0.020 0.046
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 1.3 0.024 0.048
ACVR1B activin A receptor, type IB 1.6 0.009 0.046
Genes associated with cell cycle arrest
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 1.3 0.034 0.049
RFWD3 ring finger and WD repeat domain 3 1.3 0.040 0.050
HUS1 HUS1 checkpoint homolog (S. pombe) 1.4 0.017 0.047
PMP22 peripheral myelin protein 22 1.5 0.042 0.050
CDC25C cell division cycle 25 C 1.5 0.017 0.047
WNT9A wingless-type MMTV integration site family, member 9A 1.6 0.048 0.050
CCNG2 cyclin G2 1.5 0.003 0.038
CDC7 CDC7 cell division cycle 7 (S. cerevisiae) 1.4 0.016 0.049
C12orf32 chromosome 12 open reading frame 32 1.5 0.002 0.033