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Table 2 Correlation between pTyr1068 expression and clinical outcomes stratified by EGFR mutational status

From: Phosphorylated EGFR expression may predict outcome of EGFR-TKIs therapy for the advanced NSCLC patients with wild-type EGFR

Parameter (no.of patients, %)

EGFR mutation

  

Positive

Negative

pTyr1068

+

-

p

+

-

p

Total

84

8

-

80

33

-

TKI therapy

78

8

-

69

31

-

ORR(CR + PR)

53.8(42/78)

12.5(1/8)

0.029

23.2(16/69)

3.2(1/31)

0.01

DCR

CR + PR + SD

85.9(67/78)

62.5(5/8)

0.118

69.6(48/69)

35.5(11/31)

0.001

 

PD

14.1(11/78)

37.5(3/8)

30.4(21/69)

64.5(20/31)

PFS(months)

Median

9.1

4.6

0.224

3.6

1.2

<0.001

 

95% CI

6.25-11.94

0.00-11.53

 

1.03-6.30

1.00-1.46

 
  1. Abbreviations: EGFR, epidermal growth factor receptor; pTyr, phophorylated tyrosine; CR, complete remission; PR, partial response; SD, stable disease; PD, progressive disease; ORR, objective response rate; DCR, disease control rate; PFS, progression-free survival.
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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