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Table 2 Correlation between pTyr1068 expression and clinical outcomes stratified by EGFR mutational status

From: Phosphorylated EGFR expression may predict outcome of EGFR-TKIs therapy for the advanced NSCLC patients with wild-type EGFR

Parameter (no.of patients, %) EGFR mutation
   Positive Negative
pTyr1068 + - p + - p
Total 84 8 - 80 33 -
TKI therapy 78 8 - 69 31 -
ORR(CR + PR) 53.8(42/78) 12.5(1/8) 0.029 23.2(16/69) 3.2(1/31) 0.01
DCR CR + PR + SD 85.9(67/78) 62.5(5/8) 0.118 69.6(48/69) 35.5(11/31) 0.001
  PD 14.1(11/78) 37.5(3/8) 30.4(21/69) 64.5(20/31)
PFS(months) Median 9.1 4.6 0.224 3.6 1.2 <0.001
  95% CI 6.25-11.94 0.00-11.53   1.03-6.30 1.00-1.46  
  1. Abbreviations: EGFR, epidermal growth factor receptor; pTyr, phophorylated tyrosine; CR, complete remission; PR, partial response; SD, stable disease; PD, progressive disease; ORR, objective response rate; DCR, disease control rate; PFS, progression-free survival.