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Table 3 Association between EGFR mutation and EGFR phosphorylations

From: Phosphorylated EGFR expression may predict outcome of EGFR-TKIs therapy for the advanced NSCLC patients with wild-type EGFR

Variables (no.of patients, %)

EGFR mutation

pTyr1068

pTyr1173

  

+

-

p

+

-

p

+

-

p

Total

92(44.9)

113(55.1)

 

164(80.0)

41(20.0)

 

95(57.6)

70(42.4)

 

EGFR mutation

+

   

84(91.3)

8(8.7)

<0.001

41(54.7)

34(45.3)

0.297

 

-

   

80(70.8)

33(29.2)

 

54(60.0)

36(40.0)

 

pTyr1068

+

84(51.2)

80(48.8)

<0.001

   

82(61.2)

52(38.8)

0.069

 

-

8(19.5)

33(80.5)

    

13(41.9)

18(58.1)

 

pTyr1173

+

41(43.2)

54(56.8)

0.297

82(86.3)

13(13.7)

0.069

   
 

-

34(48.6)

36(51.4)

 

52(74.3)

18(25.7)

    
  1. Abbreviations: EGFR, epidermal growth factor receptor; pTyr, phophorylated tyrosine.