|
Parameter
|
Group
|
N
|
Expression of Hsp90-beta
|
Expression of annexin A1
|
|---|
|
Low (%)
|
Moderate (%)
|
High (%)
|
χ2value
|
P value
|
Low (%)
|
Moderate (%)
|
High (%)
|
χ2value
|
P value
|
|---|
|
Gender
| | | | | | | | | | | | |
| |
Male
|
73
|
12(16.4)
|
22(30.1)
|
39(53.4)
|
4.49
|
0.105
|
18(24.7)
|
26(35.6)
|
29(39.7)
|
5.09
|
0.078
|
| |
Female
|
23
|
2(8.7)
|
3(13)
|
18(78.3)
|
2(8.7)
|
6(26.1)
|
15(65.2)
|
|
Ages
| | | | | | | | | | | | |
| |
<60
|
54
|
8(14.8)
|
13(24.1)
|
33(61.1)
|
0.251
|
0.882
|
8(14.8)
|
20(37)
|
26(48.1)
|
2.798
|
0.247
|
| |
≥60
|
42
|
6(14.3)
|
12(28.6)
|
24(57.1)
|
12(28.6)
|
12(28.6)
|
18(42.9)
|
|
Smoking
| | | | | | | | | | | | |
| |
0
|
37
|
3(8.1)
|
6(16.2)
|
28(75.7)
|
8.28
|
0.082
|
5(13.5)
|
10(27)
|
22(59.5)
|
3.856
|
0.248
|
| |
0.1–40
|
12
|
1(8.33)
|
5(41.67)
|
6(50)
|
2(16.7)
|
5(41.7)
|
5(41.7)
|
| |
>40
|
47
|
10(21.3)
|
14(29.8)
|
23(48.9)
|
13(27.7)
|
17(36.2)
|
17(36.2)
|
|
Histology
| | | | | | | | | | | | |
| |
LAC
|
39
|
8(20.5)
|
9(23.1)
|
22(56.4)★
|
8.16
|
<0.05
|
7(17.9)
|
9(23.1)
|
23(59)▴
|
7.513
|
<0.05
|
| |
LSCC
|
41
|
5(12.2)
|
13(31.7)
|
23(56.1)★
|
10(24.4)
|
19(46.3)
|
12(29.3)▴
|
| |
SCLC
|
11
|
1(9.1)
|
1(9.1)
|
9(81.82)★
|
2(18.2)
|
2(18.2)
|
7(63.6)▴
|
| |
Others
|
5
|
0(0)
|
2(40)
|
3(60)
|
1(20)
|
2(40)
|
2(40)
|
|
Pathological grade
| | | | | | | | | | | | |
| |
Poorly
|
26
|
1(3.8)
|
4(15.4)
|
21(80.8)
|
31.26
|
<0.0005
|
2(7.7)
|
2(7.7)
|
22(84.6)
|
38.26
|
<0.0005
|
| |
Moderately
|
33
|
1(3.03)
|
12(36.36)
|
20(60.61)
|
5(15.2)
|
21(63.6)
|
7(21.2)
|
| |
Well
|
22
|
11(50)
|
6(27.3)
|
5(22.7)
|
10(45.5)
|
5(22.7)
|
7(31.8)
|
| |
Undifferentiated
|
15
|
1(6.67)
|
3(20)
|
11(73.33)
|
3(20)
|
4(26.7)
|
8(53.3)
|
|
Lymphatic invasion
| | | | | | | | | | | | |
| |
N0
|
41
|
12(29.3)
|
18(43.9)
|
11(26.8)★★
|
31.02
|
<0.0005
|
17(41.5)
|
13(31.7)
|
11(26.8)▴▴
|
19.97
|
<0.0005
|
| |
N1
|
40
|
1(2.5)
|
5(12.5)
|
34(85) ★★
|
2(5.5)
|
17(34.5)
|
21(60) ▴▴
|
| |
N2
|
11
|
0(0)
|
2(18.2)
|
9(81.8) ★★
|
1(9.1)
|
1(9.1)
|
9(81.82)▴▴
|
| |
N3
|
4
|
0(0)
|
0(0)
|
4(100) ★★
|
0(0)
|
0(0)
|
4(100) ▴▴
|
|
hydrothorax
| | | | | | | | | | | | |
| |
Absent
|
82
|
13(15.9)
|
23(28)
|
46(56.1)
|
2.51
|
0.285
|
18(22)
|
29(35.4)
|
35(42.7)
|
2.25
|
0.324
|
| |
Present
|
14
|
1(7.1)
|
2(14.3)
|
11(78.6)
|
2(14.3)
|
3(21.4)
|
9(64.3)
|
|
T stage
| | | | | | | | | | | | |
| |
T1 – T2
|
57
|
11(19.3)
|
22(38.6)
|
24(42.1)
|
14.72
|
0.001
|
17(29.8)
|
23(40.4)
|
17(29.8)
|
14.83
|
0.001
|
| |
T3 – T4
|
28
|
2(7.1)
|
2(7.1)
|
24(85.7)
|
1(3.6)
|
7(25)
|
20(71.4)
|
| |
Unavailable
|
11
|
1(9.1)
|
1(9.1)
|
9(81.82)
|
2(18.18)
|
2(18.18)
|
7(63.64)
|
|
pTNM
| | | | | | | | | | | | |
| |
IB
|
3
|
1(33.3)
|
2(66.7)
|
0(0)●
|
11.449
|
0.022
|
0(0)
|
3(100)
|
0(0)●●
|
9.97
|
0.008
|
| |
IIA-IIB
|
53
|
10(18.9)
|
19(35.8)
|
24(45.3)●
|
16(30.2)
|
20(37.7)
|
17(32.1)●●
|
| |
IIIA-IIIB
|
25
|
2(8)
|
3(12)
|
20(82)●
|
2(8)
|
6(24)
|
17(68)●●
|
| |
IV
|
4
|
0(0)
|
0(0)
|
4(100)●
|
0(0)
|
1(25)
|
3(75)●●
|
| |
Unavailable
|
11
|
1(9.1)
|
1(9.1)
|
9(81.82)
|
2(18.18)
|
2(18.18)
|
7(63.64)
|
|
Imaging
| | | | | | | | | | | | |
| |
Central
|
43
|
5(11.63)
|
15(34.88)
|
23(53.49)
|
2.68
|
0.261
|
11(20.9)
|
16(41.9)
|
16(37.2)
|
2.07
|
0.356
|
| |
Ambient
|
49
|
9(18.37)
|
10(24.49)
|
30(57.14)
|
8(20.4)
|
16(32.7)
|
25(46.9)
|
| |
Unavailable
|
4
|
0(0)
|
0(0)
|
4(100)
| | |
1(25)
|
0(0)
|
3(75)
| | |
- ★p < 0.05, SCLC compared with LSCC and LAC, respectively; ▴p < 0.05, LSCC compared with LAC and SCLC, respectively; ★★p<0.0005, N0 compared with N1, N2, and N3, respectively; ▴▴p<0.0005, N0 compared with N1, N2, and N3, respectively; ●p = 0.022, IB and IIA-IIB compared with IIIA-IIIB and IV, respectively; ●●p = 0.022, IB and IIA-IIB compared with IIIA-IIIB and IV, respectively; LAC, lung adenocarcinoma; LSCC, lung squamous cell carcinoma; SCLC, small cell lung cancer; LCLC, large cell lung cancer; Smoking, pack years of smoking.
