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Figure 4 | Journal of Experimental & Clinical Cancer Research

Figure 4

From: Knockdown of clusterin sensitizes pancreatic cancer cells to gemcitabine chemotherapy by ERK1/2 inactivation

Figure 4

Inhibition of ERK1/2 sensitizes BxPC-3 and MIAPaCa-2 cells to gemcitabine -induced apoptosis. BxPC-3 and MIAPaCa-2 cells were treated with 5 μM PD98059 for 18 hours ,then the cells were exposed to 1.0 μM gemcitabine for 24 hours. Gemcitabine -induced cell death was determined by FACS. All values represent the means ± SD for duplicate determinations performed on three separate occasions. * Significantly greater than values obtained for cells cultured in the absence of PD98059; P <0.05).

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