Table 4 Association of disease control rate (DCR) with examined biomarkers
Response | ||||
|---|---|---|---|---|
Disease control | Disease progression | p-value | ||
N (%) | N (%) | |||
Gene status | ||||
KRAS (N=30) | WT | 7 (0) | 20 (87) | 0.999 |
Mutated | 0 (0) | 3 (13) | ||
EGFR (N=33) | WT | 1 (17) | 21 (78) | 0.010 |
Mutated | 5 (83) | 6 (22) | ||
IHC | ||||
EGFR (HIRSCH) (N=45) | Negative | 8 (73) | 30 (88) | 0.337 |
Positive | 3 (27) | 4 (12) | ||
pEGFR (N=43) | Negative | 4 (36) | 15 (47) | 0.728 |
Positive | 7 (64) | 17 (53) | ||
cMET (N=42) | Negative | 5 (50) | 17 (53) | 0.999 |
Positive | 5 (50) | 15 (47) | ||
FISH | ||||
EGFR (N=45) | Negative | 5 (56) | 34 (94) | 0.005 |
High polysomy | 2 (22) | 0 (0) | ||
Amplified | 2 (22) | 2 (6) | ||
EGFR (N=45) | Negative | 5 (56) | 34 (94) | 0.010 |
Positive | 4 (44) | 2 (6) | ||
D7S486 (N=37) | Deletion | 3 (43) | 12 (40) | 0.999 |
Normal | 4 (57) | 18 (60) | ||
MET (N=43) | Negative | 11 (100) | 31 (97) | 0.999 |
Positive | 0 (0) | 1 (3) | ||