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Table 1 Survival times of F98 glioma-bearing rats after prolonged infusion of carboplatin with or without 6 MV X-irradiation from a LINAC source

From: Intracerebral delivery of Carboplatin in combination with either 6 MV Photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma

Group Treatmenta

N

Survival time (days)b

% increased life span

  

Range

Mean ± SE

Median

Mean

Median

Carboplatin

7

25-180 (1)b

71 ± 7 c

52

122 c

58

Carboplatin + 6MV

11

18-180 (6)b

126 ± 8 c

>180 c

294c

>445 c

X-irradiation

      

6MV X-irradiation

7

33-62

40 ± 3

38

25

15

Untreated controls

5

26-35

32 ± 2

33

-

-

  1. a Stereotactic intracerebral implantation of 103 F98 glioma cells was carried out on d 0. Carboplatin (72 μg or 194 nmol) was administered over d 7–13 by means of Alzet osmotic pumps at a flow rate of 1 μL/h after which the pumps were removed.
  2. b Day 180 was the endpoint of the experiment. Rats still alive at this time were euthanized. The number in parenthesis indicates the number of rats surviving for more than 180 days (censored data).
  3. c Mean, median, or % increased life span were based on censored data.