Group Treatmenta | N | Survival time (days)b | % increased life span |
---|
| | Range | Mean ± SE | Median | Mean | Median |
---|
Carboplatin | 7 | 25-180 (1)b | 71 ± 7 c | 52 | 122 c | 58 |
Carboplatin + 6MV | 11 | 18-180 (6)b | 126 ± 8 c | >180 c | 294c | >445 c |
X-irradiation | | | | | | |
6MV X-irradiation | 7 | 33-62 | 40 ± 3 | 38 | 25 | 15 |
Untreated controls | 5 | 26-35 | 32 ± 2 | 33 | - | - |
- a Stereotactic intracerebral implantation of 103 F98 glioma cells was carried out on d 0. Carboplatin (72 μg or 194 nmol) was administered over d 7–13 by means of Alzet osmotic pumps at a flow rate of 1 μL/h after which the pumps were removed.
- b Day 180 was the endpoint of the experiment. Rats still alive at this time were euthanized. The number in parenthesis indicates the number of rats surviving for more than 180 days (censored data).
- c Mean, median, or % increased life span were based on censored data.