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Table 4 Pairwise concordance between methods for KRAS mutation detection

From: A comparison of Direct sequencing, Pyrosequencing, High resolution melting analysis, TheraScreen DxS, and the K-ras StripAssay for detecting KRAS mutations in non small cell lung carcinomas

  

Direct sequencing

TheraScreen DxS

K-ras StripAssay

Pyrosequencing

HRM

 

+

-

+

-

+

-

+

-

+

-

Direct sequencing

+

 

0.338

 

0.257

 

0.735

 

0.537

 

-

        

TheraScreen DxS

+

5

15

 

0.790

 

0.555

 

0.739

 

-

1

110

      

K-ras StripAssay

+

5

21

19

7

 

0.438

 

0.500

 

-

1

104

1

104

    

Pyrosequencing

+

6

4

9

1

9

1

 

0.687

 

-

0

121

11

110

17

104

  

HRM

+

6

9

12

3

11

4

9

6

 
 

-

0

99

4

95

12

87

1

98

  
  1. Every intersection of method row and method column corresponds to a 2x2 contingency table for two methods. The upper right part of the table is filled with κ concordance metrics.