Table 3 Multivariate statistic of gender, age, histology, smoking status, treat line, EGFR mutation and SFRP5 methylation for objective response rate (ORR) and disease control rate (DCR)
Variable | Objective response rate (ORR) | Disease control rate (DCR) | ||||
|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||
P value | P value | Hazard ratio (95% CI) | P value | P value | Hazard ratio (95% CI) | |
Gender (male / female) | 0.188 | 0.881 | 0.926 (0.337-2.542) | 0.001 | 0.115 | 2.117 (0.834-5.734) |
Age (≤65 / >65) | 0.351 | 0.078 | 2.295 (0.912-5.772) | 0.291 | 0.791 | 1.110 (0.515-2.393) |
Histology (adenocarcinoma / nonadenocarcinoma) | 0.002 | 0.006 | 6.680 (1.712-26.057) | 0.049 | 0.244 | 1.663 (0.707-3.915) |
Line Treatment (first line / not-first line) | 0.016 | 0.078 | 2.184 (0.917-5.200) | 0.940 | 0.491 | 0.756 (0.341-1.678) |
Smoking Status (smoker / nonsmoker) | 0.016 | 0.262 | 0.526 (0.171-1.617) | 0.001 | 0.188 | 0.524 (0.200-1.371) |
EGFR Mutation (wide type / mutation) | <0.0001 | <0.0001 | 7.695 (2.895-20.454) | <0.0001 | 0.002 | 3.255 (1.540-6.881) |
SFRP5 Methylation (methylated / unmethylated) | 0.222 | 0.650 | 0.734 (0.193-2.788) | 0.04 | 0.106 | 0.434 (0.158-1.193) |