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Table 2 High dose chemotherapy regimen in the high-dose chemotherapy group (N=60)

From: Are there candidates for high-dose chemotherapy in ovarian carcinoma?

  N (%)
Carboplatin AUC 18 12 (20)
Cyclophosphamide 60mg/kg/d (d-3 to d-2) + melphalan 140 mg/m2 d-1 32 (53)
Cycle 1: cyclophosphamide 60mg/kg/d (d-3 to d-2) + melphalan 140 mg/m² d-1 +  
Cycle 2: thiotepa 300mg/m²/d d-3 to d-2 8 (13)
Melphalan 140 mg/m² d-1 3 (5)
Thiotepa 300mg/m²/d d-3 to d-2 1 (2)
Cycle 1: melphalan 140 mg/m² d-1 + Cycle 2: thiotepa 300mg/m²/d d-3 to d-2 2 (3)
Topotecan 7,5mg/m²/d (d-6 to d-2) 2 (3)*
  1. N, number of patients; AUC, area under curve; d, day; *, patients treated in the ITOV 01 trial.