Polymorphisms in the p63 and p73 genes are associated with ovarian cancer risk and clinicopathological variables

Table 1 Distributions of select variables (covariate data) in the cases and controls and test of the Hardy-Weinberg equilibrium for the SNPs

Variables	Cases, n = 308	Controls, n = 324	P
Age, year (mean ± SD)	52.90 ± 13.26	49.89 ± 13.48	0.082
Body mass index, kg/m²			0.23
< 23	85 (27.6)	92 (28.4)
23-29	157 (51.0))	178 (54.9))
≥ 29	66 (21.4)	54 (16.7)
Number liveborn, n (%)			0.064
0	19 (6.2)	17 (5.2)
1-2	227 (73.7)	258 (79.6)
≥ 3	62 (20.1)	49 (15.1)
Oral contraceptive use, n (%)			0.49
never	184 (59.7)	201 (62.0)
1-48 months	55 (17.9)	47 (14.5)
≥ 48 months	69 (22.4)	76 (23.5)
Cigarette smoking			0.76
Yes	6 (1.9)	4 (1.2)
No	302 (98.1)	320 (98.8)
Ovarian caner family history			0.003^a
Yes	29 (9.4)	7 (2.2)
No	279 (90.6)	317 (97.8)
Hardy-Weinberg equilibrium			> 0.05^b
rs 4648551	χ2 = 22.3; P =0.98	χ2 = 0.05; P =0.99
rs 6695978	χ2 = 0.04; P =0.81	χ2 = 10.19; P =0.85
rs 873330	χ2 = 0.16; P =0.72	χ2 = 0.10; P =0.75

a. There are no statistically significant differences between the two groups in the select variables (covariate data) except ovarian cancer family history.
b. P >0.05 indicate genotype distributed frequencies in the cases and controls conformed with Hardy-Weinberg genetic equilibrium.

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