Table 2 Relationship between MMP-2, MMP-9 and type IV collagen expression and clinic-pathological parameters in 48 patients with tongue carcinoma
Variable | MMP-2 | MMP-9 | Type IV collagen | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Stromal cells | P | Tumour cells | P | Stromal cells | P | Tumour cells | P | Low | High | P | ||||||
Low | High | Low | High | Low | High | Low | High | |||||||||
Gender | Male | 14 | 22 | 1.000 | 31 | 5 | 1.000 | 6 | 30 | 0.672 | 11 | 25 | 1.000 | 24 | 12 | 0.139 |
Female | 5 | 7 | 11 | 1 | 3 | 9 | 4 | 8 | 11 | 1 | ||||||
Age | <55 | 9 | 12 | 0.683 | 18 | 3 | 1.000 | 5 | 16 | 0.477 | 5 | 16 | 0.327 | 17 | 4 | 0.269 |
≥55 | 10 | 17 | 24 | 3 | 4 | 23 | 10 | 17 | 18 | 9 | ||||||
Differentiation | Advanced | 11 | 13 | 0.2 | 24 | 0 | 0.022â–² | 7 | 17 | 0.137 | 8 | 16 | 0.756 | 15 | 9 | 0.104 |
Medium/poor | 8 | 16 | 18 | 6 | 2 | 22 | 7 | 17 | 20 | 4 | ||||||
Clinical stage | I+II | 12 | 15 | 0.435 | 21 | 6 | 0.029â–² | 8 | 19 | 0.058 | 9 | 18 | 0.724 | 18 | 9 | 0.269 |
III+IV | 7 | 14 | 21 | 0 | 1 | 20 | 6 | 15 | 17 | 4 | ||||||
T stage | T1+T2 | 19 | 26 | 0.267 | 40 | 5 | 0.336 | 9 | 36 | 1.000 | 15 | 30 | 0.542 | 32 | 13 | 0.553 |
T3+T4 | 0 | 3 | 2 | 1 | 0 | 3 | 0 | 3 | 3 | 0 | ||||||
Recurrence | No | 15 | 18 | 0.217 | 28 | 5 | 0.650 | 6 | 27 | 1.000 | 12 | 21 | 0.328 | 22 | 11 | 0.182 |
Yes | 4 | 11 | 14 | 1 | 3 | 12 | 3 | 12 | 13 | 2 | ||||||
Lymph node involvement | No | 10 | 1 | <0.001★ | 11 | 0 | 0.313 | 6 | 5 | 0.002★ | 8 | 3 | 0.002★ | 5 | 6 | 0.048▲ |
Yes | 9 | 28 | 31 | 6 | 3 | 34 | 7 | 30 | 30 | 7 | ||||||