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Table 7 Cost of adverse event management for most commonly prescribed agents (occurring in ≥ 5% of patients

From: The cost of unresectable stage III or stage IV melanoma in Italy

Category of adverse event management Most frequent medical agent(s) Percentage of events treated with agent Unit cost per day (€ 2009) Mean duration (days) Cost per event (€ 2009)
Antiemetics and antinauseants Ondansetron (1), (2) 90,7 5,99 66,5 56,9
Drugs for acid related disorders Omeprazole 75 0,25 99,5 24,9
Corticosteroids for systemic use Dexamethasone 50 0,8 133,3 106,6
Analgesics Co-efferalgan 30,8 0,52 48,5 25,2
  Tramadol 30,8 1,92 25,5 49
Drugs for functional gastrointestinal disorders Metoclopramide 100 0,92 97,5 89,7
Immunostimulants Filgrastim (3) 44,4 65,42 23,2 785
  Lenograstim 11,1 79,39 12 952,7
  Pegfilgrastim (4) 11,1 902,48 71 3051,2
  1. (1) Assumed maximum duration 3 days per 21-day cycle throughout observed mean duration.
  2. (2) Unit cost is per day, given once per 21-day cycle throughout observed mean duration.
  3. (3) Assumed maximum duration 12 days; if observed mean duration of 23,2 days is used, then total cost is 1517,7.
  4. (4) Unit cost is per cycle, given once per 21-day cycle throughout observed mean duration.