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Figure 1 | Journal of Experimental & Clinical Cancer Research

Figure 1

From: Tumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma

Figure 1

Expression of DJ-1 in SSCC clinical samples and univariate survival analysis. A. DJ-1 staining showed low expression of DJ-1 in adjacent non-cancerous tissues, and high expression of DJ-1 was found in cytoplasm of SSCC tumor tissues (IHC, 400X). In comparison, PTEN staining of adjacent non-cancerous tissues was stronger and more common than that of SSCCs (IHC, 400X). B. Fluorescent-IHC clearly demonstrates that strong expression of DJ-1 is found in cytoplasm of SSCC tumor cells, while poor staining of PTEN was observed in cytoplasm of SSCC tumor cells, and that strong expression of PTEN is found in cytoplasm of adjacent non-cancerous cells, while poor staining of DJ-1 was observed in cytoplasm of adjacent non-cancerous cells (IHC, 400X). C. Kaplan-Meier curves with univariate analyses (log-rank) comparing tumors with low- grade DJ-1 expression with those with high-grade DJ-1 expression. Patients with low-grade DJ1 expression had a cumulative 5-year survival rate of 88.0% compared with 53.9% for patients with high-grade DJ-1 expression.

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