The relationship between the plasma levels of miR-21, miR-128 and miR-342-3p and classification of glioma. (A) Levels of miR-21 were up-regulated in grade II in comparison with control cohorts and much higher in grade III cohorts than in grade II cohorts, however there were no significant difference between glioblastoma patients (grade IV) and grade III cohorts or grade II cohorts. (B) Levels of miR-128 were significantly lower in grade II cohorts than in normal cohorts, much lower in grade III cohorts and in glioblastoma patients than in grade II cohorts (P < 0.001), there were no significant difference between glioblastoma patients and grade III cohorts. (C) Levels of miR-342-3p were significant difference among all formation. *P<0.008 in comparison with normal, #P < 0.008 in comparison with glioma II, △P < 0.008 in comparison with glioma III.