Table 1 Association of Ku80 expression with clinical characteristics of 106 patients with lung adenocarcinoma
From: Ku80 is highly expressed in lung adenocarcinoma and promotes cisplatin resistance
Characteristics | patients (n = 106) | Ku80 mRNA level | P | Ku80 protein level | P | ||
|---|---|---|---|---|---|---|---|
Low (n = 28) | High (n = 78) | Low ( n = 23) | High (n = 83) | ||||
Age at diagnosis of lung AC | 0.202 | ||||||
mean ± SD | 58.33 ± 10.50 | 57.45 ± 9.96 | 60.79 ± 11.71 | ||||
Gender | 0.371 | 0.151 | |||||
Male | 43(40.6) | 9(32.1) | 34(43.6) | 6(26.1) | 37(40.6) | ||
Female | 63(59.4) | 19(67.9) | 44(56.4) | 17(73.9) | 46(55.4) | ||
Smoking status | 0.238 | 0.13 | |||||
Never | 32(30.2) | 11(39.3) | 21(26.9) | 10(43.5) | 22(26.5) | ||
Former and current smokers | 74(69.8) | 17(60.7) | 57(73.1) | 13(56.5) | 61(73.5) | ||
Tumor grade | 0.062 | 0.114 | |||||
Well differentiated | 36(34.0) | 15(53.6) | 21(34.0) | 12(52.2) | 24(28.9) | ||
Moderately differentiated | 32(30.2) | 7(25.0) | 32(30.2) | 5(21.7) | 27(32.5) | ||
Poorly differentiated | 38(35.8) | 6(21.4) | 32(35.8) | 6(26.1) | 32(38.6) | ||
Lymph node metastasis | 0.001 | 0.001 | |||||
Positive | 73(68.9) | 11(39.3) | 62(79.5) | 6(26.1) | 67(80.7) | ||
Negative | 33(31.1) | 17(60.7) | 16(20.5) | 17(73.9) | 16(19.3) | ||
Disease stage | 0.014 | 0.017 | |||||
I | 23(21.7) | 10(35.7) | 13(16.7) | 10(43.5) | 13(21.7) | ||
II | 57(53.8) | 13(46.4) | 44(56.4) | 9(39.1) | 48(53.8) | ||
III | 26(24.5) | 5(17.9) | 21(26.9) | 4(17.4) | 22(26.5) | ||