Figure 2
Morphological and phenotypic changes in paired liver metastases pre- and post- 90Y-RE. A. Example of histological features in a pre-90Y-RE CRC liver metastasis with focal areas of necrosis (a), in a post-90Y-RE CRC liver metastasis with evident increase of tumor necrosis (b) and, within uninvolved peritumoral liver parenchyma, showing dysplastic hepatocytes, sinusoidal dilatation, leukocyte infiltration and bile-duct proliferation (c). B. Histogram summarizing Sirtex response in the 13 autologous liver biopsies according to biomarker changes pre- and post- therapy. Two patients (25%) not showing biomarker changes suffered PD whereas 6 patients (100%) showing biomarker changes had PR or SD.