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Table 1 Common copy number genomic alterations in NSCLC found in two cohorts: TCGA and EGFR mutant, non-smoking Asians

From: SOX7 is down-regulated in lung cancer

Region of Chromosome

Candidate target genes

Gain of 1q21.1q-24.2

Large fragment

Gain of 5p13.2

SKP2

Gain of 7p11.2

EGFR

Gain of 8q24.3

PTP4A3

Gain of 8q24.21

MYC, PVT1

Gain of 8q24.12

MTBP

Loss of 8p23.1

UNQ9391, RP1|1, SOX7

Gain of 11q13.2-13.3

CYCLIN D1, FGF3, FGF4, FGF19

Gain 12q14.2

TBK1, RASSF3

Gain 12q14.3

HMGA2

Gain of 12q13.3-14.1

CDK4

Gain of 12q12.1

KRAS

Gain of 12q11.21

DDX11

Gain 14q13.3

PAX9

Gain of 17q12

Her2

Gain of 17q25.3

TK1, BIRC5

  1. Common genomic alterations found in both NSCLC samples with EGFR mutations (9 samples) and those from the TCGA data base [56 samples, probably these rarely have an EGFR mutation (Zhou et al. [14])].