Figure 1

Decrease expression of miR-20a in HCC is associated with tumor recurrence and poor prognosis following LT. (A) Expression of miR-20a was measured in 100 FFPE HCC samples, 10 normal liver tissue, normal liver cell line LO2 and 3 HCC cell lines by qRT-PCR, and the expression levels of miR-20a were normalized to U6 RNA expression for subsequent analyses. (B) The expression levels of miR-20a were further down-regulated in HCC samples of patients with tumor recurrence after LT. (C) The expression levels of miR-20a were much lower in the patients who had died after LT than the patients who still survived. (D and E) Kaplan-Meier analyses of overall survival and recurrence-free survival in 100 patients with HCC following LT according to the expression levels of miR-20a.