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Table 2 Univariate and multivariate Cox regression analyses of overall survival in 100 HCC patients following LT

From: Decrease expression of microRNA-20a promotes cancer cell proliferation and predicts poor survival of hepatocellular carcinoma

Parameter

Univariate analysis

Multivariable analysis

HR

95% CI

P-value

HR

95% CI

P-value

Age

0.875

0.912-1.172

0.169

-

-

-

Gender

1.034

0.561-1.907

0.915

-

-

-

HBV infection

0.342

0.261-0.745

0.230

-

-

-

Cirrhosis

0.833

0.495-1.438

0.467

-

-

-

Tumor size

1.319

1.012-1.894

0.021*

1.175

0.981-1.857

0.035*

Tumor stage (III)

2.938

1.359-5.493

0.018*

2. 354

0.846-2.943

0.851

Histologic grade (G3/G1-2)

3.342

1.837-6.421

0.009*

1.773

0.732-3.101

0.082

Milan criteria (out)

1.756

1.043-3.433

0.017*

1.365

0.935-2.778

0.347

AFP >400 (ng/ml)

2.027

1.386-3.543

0.023*

1.569

1.031-4.603

0.031*

Micro-vascular invasion

3.739

1.929-6.758

0.005*

2.671

1.756-5.545

0.009*

miR-20a (low)

4.483

2.769-9.572

0.009*

4.937

2.221-9.503

0.022*

  1. Note: *statistically significant difference.
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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