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Table 2 The decrease protein level of Notch1 and Hes-1 after treatments in renal cell lines

From: Inhibition of ADAM-17 more effectively down-regulates the Notch pathway than that of γ-secretase in renal carcinoma

 

Notch1 with Marimastat

Notch1 with DAPT

P value

Hes-1 with Marimastat

Hes-1 with DAPT

P value

786-O cell

0.397±0.126

0.364±0.068

P<0.05

0.411±0.096

0.391±0.099

P<0.05

OS-RC-2 cell

0.405±0.086

0.221±0.107

P<0.05

0.414±0.909

0.348±0.108

P<0.05

  1. The expression of Notch 1 and HES-1 proteins was more readily decreased in the Marimastat treated renal carcinomas than in those treated by DAPT (786-O Notch1 P<0.05 Hes-1 P<0.05; OS-RC-2 Notch1 P<0.05 Hes-1 P<0.05).