From: Inhibition of ADAM-17 more effectively down-regulates the Notch pathway than that of γ-secretase in renal carcinoma
Notch1 with Marimastat
Notch1 with DAPT
P value
Hes-1 with Marimastat
Hes-1 with DAPT
786-O cell
0.397±0.126
0.364±0.068
P<0.05
0.411±0.096
0.391±0.099
OS-RC-2 cell
0.405±0.086
0.221±0.107
0.414±0.909
0.348±0.108