From: Detection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer
Total (%) | E2A-PBX1 positive (%) | E2A-PBX1 negative (%) | P value | Median overall survival (95% CI) | P value | ||
---|---|---|---|---|---|---|---|
Total | 184 (100) | 23 (12.5) | 161 (87.5) | 105.60 (55.41 ~ 155.79) | |||
Age | |||||||
Mean (years) | 66.9 ± 12.0 | 66.0 ± 11.7 | 67.0 ± 12.1 | 0.698* | |||
Range (years) | 25-91 | 39-84 | 25-91 | ||||
<71 | 109 (100) | 13 (11.9) | 96 (88.1) | 0.777 | 69.00 (43.73 ~ 94.27) | 0.7069 | |
≥71 | 75 (100) | 10 (13.3) | 65 (86.7) | 105.60 (18.53 ~ 192.67) | |||
Gender | 0.215 | ||||||
Male | 78 (100) | 7 (9.0) | 71 (91.0) | 64.70 (NA) | 0.0889 | ||
Female | 106 (100) | 16 (15.1) | 90 (84.9) | 105.60 (57.58 ~ 153.62) | |||
Race | 0.606 | 0.1430 | |||||
Caucasian | 136 (100) | 17 (12.5) | 119 (87.5) | 81.70 (52.59 ~ 110.81) | |||
Asian | 27 (100) | 3 (11.1) | 24 (88.9) | 64.70 (45.79 ~ 83.61) | |||
Hispanic | 7 (100) | 2 (28.6) | 5 (71.4) | NR | |||
African-American | 7 (100) | 0 | 7 (100) | NR | |||
Others | 7 (100) | 1 (14.3) | 6 (85.7) | ||||
Smoking | 0.174 | 0.0868 | |||||
Smoker | 127 (100) | 19 (15.0) | 108 (85.0) | 69.00 (42.36 ~ 95.64) | |||
Non-smoker | 53 (100) | 4 (7.5) | 49 (92.5) | 105.60 (35.86 ~ 175.34) | |||
Unknown | 4 (100) | 0 | 4 (100) | ||||
Pack/Year (smoker) | |||||||
Mean | 41.6 ± 23.5 | 46.3 ± 26.7 | 30.9 ± 35.9 | 0.623* | |||
Range | 1-160 | 5-90 | 1-160 | ||||
Gender × Smoking | 0.097 | 0.0258 | |||||
Male, Smoker | 59 (100) | 5 (8.5) | 54 (91.5) | 0.7331 | 56.20 (27.25 ~ 85.15) | 0.07491 | |
Male, Non-smoker | 18 (100) | 2 (11.1) | 16 (88.9) | NR | |||
Female, Smoker | 68 (100) | 14 (20.6) | 54 (79.4) | 0.0482 | 81.70 (41.68 ~ 121.72) | 0.67142 | |
Female, Non-smoker | 35 (100) | 2 (5.7) | 33 (94.3) | 105.60 (35.04 ~ 176.16) | |||
Unkown | 4 (100) | 0 | 4 (100) | ||||
Histology | 0.276 | 0.6013 | |||||
AIS | 76 (100) | 17 (22.4) | 59 (77.6) | 0.0063 | 105.60 (57.93 ~ 153.27) | 0.12083 | |
Invasive adenocarcinoma | 76 (100) | 5 (6.6) | 71 (93.4) | 53.10 (NA) | |||
Squamous cell carcinoma | 18 (100) | 0 | 18 (100) | NR | |||
Carcinoid | 6 (100) | 0 | 6 (100) | NR | |||
Large | 4 (100) | 1 (25.0) | 3 (75.0) | NR | |||
Others | 4 (100) | 0 | 4 (100) | ||||
Tumor Size | 0.026* | ||||||
Mean | 3.3 ± 1.9 | 4.1 ± 2.8 | 3.2 ± 1.7 | ||||
Range | 0.5-13.0 | 0.9-12.0 | 0.5-13.0 | ||||
Pathological TNM Classification | |||||||
pt | pt1 | 74 (100) | 9 (12.2) | 65 (87.8) | 0.408 | 105.60 (NA) | 0.0915 |
pt2 | 81 (100) | 9 (11.1) | 72 (88.9) | 69.00 (44.22 ~ 93.78) | |||
pt3 | 8 (100) | 0 | 8 (100) | 40.20 (26.06 ~ 54.34) | |||
pt4 | 18 (100) | 4 (22.2) | 14 (77.8) | 30.50 (NA) | |||
Unknown | 3 (100) | 1 (33.3) | 2 (66.6) | ||||
pn | pn0 | 144 (100) | 18 (12.5) | 126 (87.5) | 0.924 | 105.60 (65.68 ~ 145.52) | 0.0038 |
pn1 | 19 (100) | 3 (15.8) | 16 (84.2) | 47.80 (32.55 ~ 63.05) | |||
pn2 | 17 (100) | 2 (11.8) | 15 (88.2) | 45.50 (NA) | |||
pn3 | 2 (100) | 0 | 2 (100) | 5.20 (NA) | |||
Unknown | 2 (100) | 0 | 2 (100) | ||||
pm | pm0 | 171 (100) | 20 (11.7) | 151(88.3) | 0.179 | 105.60 (55.99 ~ 155.21) | 0.2605 |
pm1 | 12 (100) | 3 (25.0) | 9 (75.0) | 56.20 (35.26 ~ 77.14) | |||
Pathological Stage | 0.426 | 0.0167 | |||||
Stage I | 119 (100) | 13 (10.9) | 106 (89.1) | 105.60 (65.47 ~ 145.73) | |||
Stage II | 22 (100) | 2 (9.1) | 20 (90.9) | NR | |||
Stage III | 29 (100) | 5 (17.2) | 24 (82.8) | 33.60 (0.00 ~ 73.11) | |||
Stage IV | 12 (100) | 3 (25.0) | 9 (75.0) | 56.20 (35.26 ~ 77.14) | |||
Unknown | 2 (100) | 0 | 2 (100) | ||||
Recurrence | 0.435 | <0.001 | |||||
Yes | 63 (100) | 6 (9.5) | 57 (90.5) | 39.30 (30.45 ~ 48.15) | |||
No | 103 (100) | 14 (13.6) | 89 (86.4) | NR | |||
Unknown | 18 (100) | 1 (5.6) | 17 (94.4) |