Cinnamic acid induces apoptotic cell death and cytoskeleton disruption in human melanoma cells

Table 1 Effect of cinnamic acid on cell cycle of HT-144 and NGM cells after 48 h exposure

Cell line	Cell cycle phases	Control groups	Treated groups
			0.4 mM	3.2 mM
HT-144	Hypodiploid cells	13.80 ± 3.49	15.38 ± 0.86	25.78 ± 2.85^a
	G0/G1 phases	42.90 ± 4.37	45.12 ± 2.32	47.99 ± 5.30
	S phase	16.08 ± 2,49	12.22 ± 2.01	6.35 ± 1.21^b
	G2/M phases	18.69 ± 4.10	19.95 ± 1.95	15.07 ± 2.04
	Polyploid cells	9.16 ± 3.14	7.80 ± 2.43	5.19 ± 1.84
NGM	Hypodiploid cells	11.25 ± 3.88	8.51 ± 3.10	43.31 ± 5.46^b
	G0/G1 phases	64.81 ± 3.43	64.72 ± 7.43	40.46 ± 3.94^b
	S phase	5.59 ± 1.56	4.48 ± 1.43	2.24 ± 1.01
	G2/M phases	13.67 ± 1.43	16.82 ± 2.36	10.93 ± 3.65
	Polyploid cells	4.93 ± 1.45	5.70 ± 1.27	3.21 ± 1.46

The numbers represent the frequency of cells (%) in each phase of the cell cycle according to DNA quantification by flow cytometry. Results are showed as Mean ± SD.
^a Significantly different (p≤0.01) from control group and 0.4 mM treated group.
^b Significantly different (p≤0.05) from control group.

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