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Table 4 Effect of cinnamic acid on formation of nuclear aberrations in NGM and HT-144 cells after 48 h exposure

From: Cinnamic acid induces apoptotic cell death and cytoskeleton disruption in human melanoma cells

Cell line

Group

Micronucleated cells

Cells with nuclear buds

Binucleated cells

Multinucleated cells

HT-144

Control

1.97 ± 0.04

0.20 ± 0.05

1.83 ± 0.02

0.43 ± 0.06

0.05 mM

2.01 ± 0.06

0.24 ± 0.06

1.79 ± 0.04

0.52 ± 0.03

0.40 mM

3.13 ± 1.03a

0.40 ± 0.02

4.23 ± 1.03a

0.67 ± 0.04

3.20 mM

6.07 ± 1.45b

1.30 ± 0.02b

5.87 ± 0.98a

1.17 ± 0.12a

NGM

Control

1.38 ± 0.06

0.15 ± 0.01

0.20 ± 0.03

0.05 ± 0.02

0.05 mM

1.27 ± 0.04

0.19 ± 0.04

0.29 ± 0.02

0.25 ± 0.08

0.40 mM

1.15 ± 0.01

0.10 ± 0.03

0.37 ± 0.07

0.00 ± 0.00

 

3.20 mM

3.07 ± 0.03a

0.44 ± 0.02a

0.53 ± 0.06

0.00 ± 0.00

  1. The numbers represent the frequency of cells (%) with nuclear alterations. Results are showed as Mean ± SD.
  2. a Significantly higher (p ≤ 0.05) than control group.
  3. b Significantly higher (p ≤ 0.05) than control group, group treated with 0.05 mM and group treated with 0.4 mM cinnamic acid.