Figure 2

Expression of glucose transporter and glucose metabolizing enzymes in gastric cancer. (a) Glucose transporter 1 (GLUT1) staining was strong in the cell walls of tubular (a1) and poorly differentiated adenocarcinomas (a2). (b) Staining for hexokinase 2 (HK2) was seen in the cytoplasm of tubular (b1) and poorly differentiated adenocarcinomas (b2). (c) Increased mRNA expression of glucose metabolism-related proteins was observed with HK2 and GLUT1, but not HK1 and Glucose-6-phosphatase (G6Pase). (d-e) Spearman’s correlation analysis found no association between standardized uptake value (SUV) and HK2 (d) or GLUT1 (e) mRNA expression. Values are expressed as mean ± SEM. *P < 0.05. GLUT1; Glucose transporter 1, G6Pase; Glucose-6-phosphatase, HK1; Hexokinase 1, HK2; Hexokinase 2, SUV; Standardized Uptake Value.