Figure 4
Expression of glucose metabolism-related proteins in intestinal and non-intestinal gastric cancers. Hexokinase 1 (HK1) mRNA levels were similar to those in normal mucosa, while HK2 mRNA levels were higher in both intestinal and non-intestinal gastric cancers (P < 0.01). Glucose transporter 1 (GLUT1) expression increased more in intestinal tumors than in normal mucosa (P < 0.01), but were unchanged in non-intestinal tumors. Glucose-6-phosphatase (G6Pase) expression decreased, but the difference was not significant. The mRNA expression of proliferating cell nuclear antigen (PCNA) and hypoxia-inducible factor 1α (HIF1α) increased more than three-fold compared to normal mucosa (P < 0.01). Data are expressed as mean ± SEM *P < 0.05 (ANOVA). GLUT1; Glucose transporter 1, G6Pase; Glucose-6-phosphatase, HIF1α; Hypoxia-inducible factor 1α, HK1; Hexokinase 1, HK2; Hexokinase 2, PCNA; Proliferating cell nuclear antigen, SUV; Standardized Uptake Value.