Skip to main content

Table 3 The analysis of FOXP3 SNPs allele frequency and genotype in all donors

From: FOXP3 gene polymorphism is associated with hepatitis B-related hepatocellular carcinoma in China

SNPs

HCC n(%)

CHB n(%)

HEAL n(%)

HCC-HEAL

 

CHB-HEAL

 

HCC-CHB

 
 

n = 392

n = 344

n = 372

OR(95% CI)

P value

OR(95% CI)

P value

OR(95% CI)

P value

Allele

         

rs2280883

    

0.20

 

0.54

 

0.06

C

134(17.1)

144(20.9)

146(19.6)

0.84(0.65-1.10)

 

1.07(0.87-1.31)

 

0.78(0.60-1.01)

 

T

650(82.9)

544(79.1)

598(80.4)

1.18(0.91-1.54)

 

0.98(0.93-1.04)

 

1.28(0.99-1.67)

 

rs3761549

    

0.03

 

0.11

 

0.58

C

630(81.2)

549(80.0)

554(76.5)

1.32(1.03-1.70)

 

1.05(0.99-1.11)

 

1.08(0.83-1.40)

 

T

146(18.8)

137(20.0)

170(23.5)

0.76(0.59-0.97)

 

0.85(0.70-1.04)

 

0.93(0.72-1.20)

 

Genotype

         

rs2280883

    

<0.001

 

<0.01

 

0.158

CC

54(13.8)

55(16.0)

41(11.0)

1.29(0.84-1.99)

 

1.54(0.99-2.37)

 

0.84(0.56-1.26)

 

TT

312(79.6)

255(74.1)

267(71.8)

1.53(1.10-2.14)

 

1.13(0.81-1.57)

 

1.38(0.98-1.95)

 

CT

26(6.6)

34(9.9)

64(17.2)

0.34(0.21-0.55)

 

0.53(0.34-0.82)

 

0.65(0.38-1.10)

 

rs3761549

    

<0.001

 

<0.001

 

0.239

CC

301(77.6)

256(74.6)

233(64.4)

1.92(1.39-2.64)

 

1.63(1.18-2.25)

 

1.18(0.84-1.65)

 

TT

59(15.2)

50(14.6)

41(11.3)

1.40(0.92-2.15)

 

1.34(0.86-2.08)

 

1.05(0.70-1.58)

 

CT

28(7.2)

37(10.8)

88(24.3)

0.24(0.15-0.38)

 

0.38(0.25-0.57)

 

0.64(0.39-1.08)

 
  1. “HEAL”: Healthy donors.