Table 4 The analysis of the association between FOXP3 genotypes and HCC clinical pathology variables
From: FOXP3 gene polymorphism is associated with hepatitis B-related hepatocellular carcinoma in China
Characteristics | rs2280883 | P values | rs3761549 | P values | ||
|---|---|---|---|---|---|---|
TT n(%) | CC/CT n(%) | CC n(%) | TT/CT n(%) | |||
n = 151 | n = 37 | n = 155 | n = 33 | |||
Age | 0.48 | 0.15 | ||||
<55 | 101(66.9) | 27(73.0) | 109(70.3) | 19(57.6) | ||
≥55 | 50(33.1) | 10(27.0) | 46(29.7) | 14(42.4) | ||
Gender | 0.216 | 0.33 | ||||
Male | 136(90.0) | 30(81.1) | 139(89.7) | 27(81.8) | ||
Female | 15(10.0) | 7(18.9) | 16(10.3) | 6(18.2) | ||
Alcohol abuse | 0.63 | 0.80 | ||||
Absent | 72(47.7) | 16(43.2) | 76(49.0) | 17(51.5) | ||
Present | 79(52.3) | 21(56.8) | 79(51.0) | 16(48.5) | ||
Tumor Size (cm) | 0.61 | 0.64 | ||||
≤5 | 42(27.8) | 9(24.3) | 44(28.4) | 7(21.2) | ||
>5, ≤10 | 57(37.7) | 11(29.7) | 54(34.8) | 14(42.4) | ||
>10, ≤20 | 43(28.5) | 14(37.9) | 48(31.0) | 9(27.3) | ||
>20 | 9(6.0) | 3(8.1) | 9(5.8) | 3(9.1) | ||
Tumor nodule (No.) | 0.54 | 0.48 | ||||
1 | 98(64.9) | 26(70.3) | 104(67.1) | 20(60.6) | ||
≥2 | 53(35.1) | 11(29.7) | 51(32.9) | 13(39.4) | ||
Tumor grade | 0.69 | 0.87 | ||||
I | 24(15.9) | 3(8.1) | 24(15.5) | 3(9.1) | ||
II | 24(15.9) | 6(16.2) | 24(15.5) | 6(18.2) | ||
III | 97(64.2) | 27(73.0) | 101(65.2) | 23(69.7) | ||
IV | 6(4.0) | 1(2.7) | 6(3.8) | 1(3.0) | ||
lymph node metastasis | 0.76 | 0.93 | ||||
Absent | 138(91.4) | 35(94.6) | 142(91.6) | 31(93.9) | ||
Present | 13(8.6) | 2(5.4) | 13(8.4) | 2(6.1) | ||
portal vein tumor thrombus | 0.76 | 0.02 | ||||
Absent | 119(78.8) | 30(81.1) | 118(76.13) | 31(93.94) | ||
Present | 32(21.2) | 7(18.9) | 37(23.87) | 2(6.06) | ||
Distant Metastasis | 0.59 | 0.73 | ||||
Absent | 136(90.1) | 35(94.6) | 142(91.6) | 29(87.9) | ||
Present | 15(9.9) | 2(5.4) | 13(8.4) | 4(12.1) | ||
Recurrence | 0.60 | 0.001 | ||||
Absent | 112(74.2) | 29(77.4) | 124(80.0) | 17(51.5) | ||
Present | 39(25.8) | 8(21.6) | 31(20.0) | 16(48.5) | ||