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Table 2 Comparison of OPN promoter between lung cancer patients and healthy controls

From: Osteopontin genetic variants are associated with overall survival in advanced non-small-cell lung cancer patients and bone metastasis

 

Controls

Patients

 

Lung cancer

 

n

n

P

LN(+)

LN(−)

P

BM(+)

BM(−)

P

−66 T/G

         

TT

351

356

1.00

221

135

1.00

77

279

1.00

TG

9

4

0.262

2

2

0.637

2

2

0.211

−156

         

G/G

155

137

1.00

83

54

1.00

26

96

1.00

G/GG

136

150

0.094

89

61

0.391

39

126

0.671

GG/GG

69

73

0.218

48

25

0.550

14

59

0.855

−443

         

TT

153

164

1

49

115

1.00

23

141

1.00

CT

163

165

0.388

93

72

<0.001

36

129

0.084

CC

44

31

0.068

25

6

<0.001

20

11

<0.001

  1. Note: LN Lymph node metastasis, BM bone metastasis. P value was calculated by chi-square test and a Fisher’s exact test.