Table 4 Different characteristics according plasma EGFR mutational status
From: Detection of EGFR mutations in circulating free DNA by PNA-mediated PCR clamping
| Â | Patients with plasma EGFR mutation | Patients without plasma EGFR mutation | P value |
|---|---|---|---|
|  | (n = 10) | (n = 50) |  |
Age | Â | Â | Â |
   Median, years | 60.5 | 63.0 | 0.76 |
   Range | 51-76 | 38-84 | |
Gender | Â | Â | Â |
   Female | 7 (70.0%) | 32 (64.0%) | 1.00 |
   Male | 3 (30.0%) | 18 (36.0%) | |
Smoking history | Â | Â | Â |
   Nonsmoker | 8 (80.0%) | 35 (70.0%) | 0.67 |
   Ex-smoker | 1 (10.0%) | 10 (20.0%) | |
   Current smoker | 1 (10.0%) | 5 (10.0%) | |
WHO Performance status | Â | Â | Â |
   Normal activity | 4 (40.0%) | 19 (38.0%) | 0.94 |
   Restricted activity | 4 (40.0%) | 23 (46.0%) | |
   In bed < 50% of the time | 2 (20.0%) | 7 (14.0%) | |
   In bed > 50% of the time | - | 1 (2.0%) | |
Tumor histology | Â | Â | Â |
   ADC | 9 (90.0%) | 44 (88.0%) | 0.83 |
   SQC | - | 3 (6.0%) | |
   LCC | - | 1 (2.0%) | |
   NSCLC NOS | 1 (10.0%) | 1 (2.0%) | |
   Others | - | 1 (2.0%) | |
Stage | Â | Â | Â |
   IIIA | - | 3 (6.0%) | 0.64 |
   IIIB | 1 (10.0%) | 3 (6.0%) | |
   IV | 9 (90.0%) | 44 (88.0%) | |
Central labotory | Â | Â | Â |
   on-site | 5 (50.0%) | 16 (32.0%) | 0.30 |
   off-site | 5 (50.0%) | 34 (68.0%) |  |