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Table 4 Different characteristics according plasma EGFR mutational status

From: Detection of EGFR mutations in circulating free DNA by PNA-mediated PCR clamping

  Patients with plasma EGFR mutation Patients without plasma EGFR mutation P value
  (n = 10) (n = 50)  
Age    
   Median, years 60.5 63.0 0.76
   Range 51-76 38-84
Gender    
   Female 7 (70.0%) 32 (64.0%) 1.00
   Male 3 (30.0%) 18 (36.0%)
Smoking history    
   Nonsmoker 8 (80.0%) 35 (70.0%) 0.67
   Ex-smoker 1 (10.0%) 10 (20.0%)
   Current smoker 1 (10.0%) 5 (10.0%)
WHO Performance status    
   Normal activity 4 (40.0%) 19 (38.0%) 0.94
   Restricted activity 4 (40.0%) 23 (46.0%)
   In bed < 50% of the time 2 (20.0%) 7 (14.0%)
   In bed > 50% of the time - 1 (2.0%)
Tumor histology    
   ADC 9 (90.0%) 44 (88.0%) 0.83
   SQC - 3 (6.0%)
   LCC - 1 (2.0%)
   NSCLC NOS 1 (10.0%) 1 (2.0%)
   Others - 1 (2.0%)
Stage    
   IIIA - 3 (6.0%) 0.64
   IIIB 1 (10.0%) 3 (6.0%)
   IV 9 (90.0%) 44 (88.0%)
Central labotory    
   on-site 5 (50.0%) 16 (32.0%) 0.30
   off-site 5 (50.0%) 34 (68.0%)  
  1. Abbreviations: ADC adenocarcinoma, SQC squamous cell carcinoma LCC large cell carcinoma, NSCLC NOS non-small cell lung cancer not otherwise specified.