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Table 5 Previous reports on EGFR mutation test from circulating free DNA

From: Detection of EGFR mutations in circulating free DNA by PNA-mediated PCR clamping

Year

Authors

Subjects

DNA concentration

Mutation test

Detection rate

2006

Kimura H, et al. [16]

Asian

70 ng/mL (range, 0–1720 ng/mL)

SARMS

48.1% (13/27)

Female : 37%

Nonsmoker : N/A

ADC : 85%

ORR : 33%

2008

Maheswaran S, et al. [24]

Western

N/A

SARMS

39% (7/18)

EGFR mutant patients

2009

He C, et al. [29]

Asian

N/A

Mutant-enriched PCR

49.3% (66/134)

Female : 37%

Nonsmoker : 53%

ADC : 75%

2009

Bai H, et al. [28]

Asian

N/A

dHPLC

34.3% (79/230)

Female : 46%

Nonsmoker : 55%

ADC : 74%

ORR : 36% (37/102)

2009

Mack PC, et al. [26]

Western/Asian : 96/4%

2.3 ng/μL (range, 1–9 ng/μL )

SARMS

20% (10/49)

Female : 56%

Nonsmoker : 53%

ADC : 67%

2009

Kuang Y, et al. [25]

Western

52.3 ng/μL (range, 10–163 ng/μL )

SARMS and WAVE/Surveyor

54% (29/54)

Female : 81.5%

Whole genome amplification

Nonsmoker : N/A

ADC : N/A

ORR : 56%

2010

Brevet M, et al. [31]

Western

N/A

Mass spectrometry genotyping assay (Sequenom) and mutant-enriched PCR

Whole genome amplification

23.2% (10/31)

Female : 52%

Nonsmoker : 45%

ADC : 97%

2010

Jian G, et al. [27]

Asian

N/A

Taqman PCR

23.2% (13/56)

Female : 46%

Nonsmoker : 58%

ADC : 78%

ORR : 30%

2011

Jiang B, et al. [30]

Asian

Minimum 4 ng/μL (range, 11–66 ng/μL )

Mutant-enriched PCR

31% (18/58)

Female : 31%

Nonsmoker : 38%

ADC : 72%

2011

Taniguchi K, et al. [32]

Asian

N/A

BEAMing

72.7% (32/44)

EGFR mutant patients

This study

Kim HR, et al.

Asian

8.6 ng/μL

PNA-based PCR clamping

16.7% (10/60)

Female : 65%

Nonsmoker : 2%

ADC : 88%

  

ORR : 100%

   
  1. Abbreviations: ADC adenocarcinoma, SARMS scorpion-amplified refractory mutation system, PCR polymerase chain reaction, dHPLC denaturing high-performance liquid chromatography, BEAMing beads, emulsion, amplification, and magnetics, PNA peptide nucleic acid.