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Table 3 Cause-specific differences in telomeric gene expression between cirrhotic/fibrotic and HCC tissue samples

From: Cause-specific telomere factors deregulation in hepatocellular carcinoma

  HBV HCV Alcohol   
  Cirrhotic and/or Fibrotic (n = 8) HCC (n = 10) p Cirrhotic and/or Fibrotic (n = 9) HCC (n = 10) p Cirrhotic and/or Fibrotic (n = 10) HCC (n = 10) p
Shelterin
POT1 0.0000 0.0000 ns 0.0125 0.0203 ns 0.0090 0.0060 ns
PTOP 0.0000 0.0000 ns 0.0037 0.0064 ns 0.0055 0.0071 ns
RAP1 0.0016 0.0000 ns 0.4210 0.5059 ns 0.4091 0.2538 ns
TIN2 0.0018 0.0033 ns 0.0510 0.0581 ns 0.0804 0.0876 ns
TRF1 0.0117 0.0209 ns 0.2271 0.1626 ns 0.2488 0.2886 ns
TRF2 0.0000 0.0000 ns 0.0061 0.0015 ns 0.0012 0.0012 ns
Non Shelterin
HMRE11A 0.0006 0.0000 ns 0.0627 0.0811 ns 0.0764 0.0536 ns
HMRE11B 0.0008 0.0000 ns 0.0492 0.0508 ns 0.0886 0.0850 ns
Ku70 0.0045 0.0024 ns 0.1704 0.2418 ns 0.1825 0.1645 ns
Ku80 0.0033 0.0015 ns 0.1209 0.1494 ns 0.1316 0.0853 ns
NBS1 0.0002 0.0024 ns 0.0304 0.0317 ns 0.0403 0.0501 ns
RAD50 0.0002 0.0000 ns 0.0091 0.0118 ns 0.0108 0.0101 ns
TANK1 0.0005 0.0000 ns 0.0788 0.0761 ns 0.0945 0.0869 ns
TANK2 0.0000 0.0006 ns 0.0188 0.0255 ns 0.0127 0.0171 ns
Pinx1 0.0001 0.0049 ns (0.054) 0.0083 0.0107 ns 0.0219 0.0165 ns