Journal of Experimental & Clinical Cancer Research

Table 3 Cause-specific differences in telomeric gene expression between cirrhotic/fibrotic and HCC tissue samples

From: Cause-specific telomere factors deregulation in hepatocellular carcinoma

	HBV			HCV			Alcohol
	Cirrhotic and/or Fibrotic (n = 8)	HCC (n = 10)	p	Cirrhotic and/or Fibrotic (n = 9)	HCC (n = 10)	p	Cirrhotic and/or Fibrotic (n = 10)	HCC (n = 10)	p
*Shelterin*
POT1	0.0000	0.0000	ns	0.0125	0.0203	ns	0.0090	0.0060	ns
PTOP	0.0000	0.0000	ns	0.0037	0.0064	ns	0.0055	0.0071	ns
RAP1	0.0016	0.0000	ns	0.4210	0.5059	ns	0.4091	0.2538	ns
TIN2	0.0018	0.0033	ns	0.0510	0.0581	ns	0.0804	0.0876	ns
TRF1	0.0117	0.0209	ns	0.2271	0.1626	ns	0.2488	0.2886	ns
TRF2	0.0000	0.0000	ns	0.0061	0.0015	ns	0.0012	0.0012	ns
*Non Shelterin*
HMRE11A	0.0006	0.0000	ns	0.0627	0.0811	ns	0.0764	0.0536	ns
HMRE11B	0.0008	0.0000	ns	0.0492	0.0508	ns	0.0886	0.0850	ns
Ku70	0.0045	0.0024	ns	0.1704	0.2418	ns	0.1825	0.1645	ns
Ku80	0.0033	0.0015	ns	0.1209	0.1494	ns	0.1316	0.0853	ns
NBS1	0.0002	0.0024	ns	0.0304	0.0317	ns	0.0403	0.0501	ns
RAD50	0.0002	0.0000	ns	0.0091	0.0118	ns	0.0108	0.0101	ns
TANK1	0.0005	0.0000	ns	0.0788	0.0761	ns	0.0945	0.0869	ns
TANK2	0.0000	0.0006	ns	0.0188	0.0255	ns	0.0127	0.0171	ns
Pinx1	0.0001	0.0049	ns (0.054)	0.0083	0.0107	ns	0.0219	0.0165	ns

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ISSN: 1756-9966

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