Figure 3
Cardiovascular effects of 1. Effect of 1 on Heart Rate (a) and QTcB Interval (b) in the Anaesthetized Guinea Pig Following Escalating Intravenous Doses of 0.25 mg/kg, 0.5 mg/kg and 1.0 mg/kg (Cumulative Dose: 1.75 mg/kg). Sequential doses of 0.25 mg/kg, 0.5 mg/kg and 1.0 mg/kg to each of three guinea pigs. Time interval between doses: 60 minutes. Plots represent mean data from three animals.