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Table 10 Univariate and multivariate survival analysis of the clinicopathological and molecular features of PDAC

From: Candidate microRNA biomarkers of pancreatic ductal adenocarcinoma: meta-analysis, experimental validation and clinical significance

Factor

 

Univariate analysis

Multivariate analysis

HR (95% CI)

p-value

HR (95% CI)

p-value

Histology

Well or moderate vs. poor

1.342 (0.621–2.901)

0.454

  

T category

T 1/2 VS. T 3/4

2.282 (1.043–4.994)

0.039

1.518 (0.666–3.460)

0.320

Lymph node metastasis

Negative vs. positive

1.935 (0.867–4.317)

0.107

  

Tumour size

<2 cm vs. ≥2 cm

1.736 (0.790–3.814)

0.170

  

Perineural invasion

None or slight vs. prominent

1.244 (0.563–2.752)

0.589

  

Margin involvement

R0 vs. R1

2.550 (1.120–5.805)

0.026

2.543 (1.093–5.918)

0.030

Vascular invasion

None or slight vs. prominent

2.542 (1.154–5.601)

0.021

1.940 (0.819–4.597)

0.132

miR-155 expression

High vs. low

2.414 (1.064–5.478)

0.035

1.365 (0.520–3.579)

0.538

miR-100 expression

High vs. low

1.480 (0.683–3.205)

0.321

  

miR-21 expression

High vs. low

2.610 (1.179–5.777)

0.018

2.599 (1.151–5.867)

0.021

miR-221 expression

High vs. low

2.001 (0.868–4.617)

0.104

  

miR-31 expression

High vs. low

2.735 (1.317-6.426)

0.039

2.637 (1.298-6.635)

0.048

miR-143 expression

High vs. low

1.516 (1.211–4.429)

0.257

  

miR-23a expression

High vs. low

1.639 (0.709–3.788)

0.248

  

miR-217 expression

Low vs. high

1.419 (1.045-4.021)

0.205

  

miR-148a expression

Low vs. high

1.739 (1.385-4.481)

0.093

  

miR-375 expression

Low vs. high

2.337 (1.431-5.066)

0.022

2.451 (1.429-5.135)

0.034

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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