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Table 10 Univariate and multivariate survival analysis of the clinicopathological and molecular features of PDAC

From: Candidate microRNA biomarkers of pancreatic ductal adenocarcinoma: meta-analysis, experimental validation and clinical significance

Factor   Univariate analysis Multivariate analysis
HR (95% CI) p-value HR (95% CI) p-value
Histology Well or moderate vs. poor 1.342 (0.621–2.901) 0.454   
T category T 1/2 VS. T 3/4 2.282 (1.043–4.994) 0.039 1.518 (0.666–3.460) 0.320
Lymph node metastasis Negative vs. positive 1.935 (0.867–4.317) 0.107   
Tumour size <2 cm vs. ≥2 cm 1.736 (0.790–3.814) 0.170   
Perineural invasion None or slight vs. prominent 1.244 (0.563–2.752) 0.589   
Margin involvement R0 vs. R1 2.550 (1.120–5.805) 0.026 2.543 (1.093–5.918) 0.030
Vascular invasion None or slight vs. prominent 2.542 (1.154–5.601) 0.021 1.940 (0.819–4.597) 0.132
miR-155 expression High vs. low 2.414 (1.064–5.478) 0.035 1.365 (0.520–3.579) 0.538
miR-100 expression High vs. low 1.480 (0.683–3.205) 0.321   
miR-21 expression High vs. low 2.610 (1.179–5.777) 0.018 2.599 (1.151–5.867) 0.021
miR-221 expression High vs. low 2.001 (0.868–4.617) 0.104   
miR-31 expression High vs. low 2.735 (1.317-6.426) 0.039 2.637 (1.298-6.635) 0.048
miR-143 expression High vs. low 1.516 (1.211–4.429) 0.257   
miR-23a expression High vs. low 1.639 (0.709–3.788) 0.248   
miR-217 expression Low vs. high 1.419 (1.045-4.021) 0.205   
miR-148a expression Low vs. high 1.739 (1.385-4.481) 0.093   
miR-375 expression Low vs. high 2.337 (1.431-5.066) 0.022 2.451 (1.429-5.135) 0.034