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Table 7 The ten most strongly enriched GO processes and pathways with respect to the meta-signature miRNA candidates

From: Candidate microRNA biomarkers of pancreatic ductal adenocarcinoma: meta-analysis, experimental validation and clinical significance

GO processes    
  Process Hyp* Genes
  0006355: regulation of transcription, DNA-dependent 1.94E-31 128
  0045944: positive regulation of transcription from RNA polymerase II promoter 2.21E-18 73
  0045893: positive regulation of transcription, DNA-dependent 7.64E-14 89
  0007275: multicellular organismal development 1.99E-13 57
  0007165: signal transduction 1.16E-10 69
  0007399: nervous system development 8.52E-10 74
  0006915: apoptotic process 1.76E-09 57
  0045892: negative regulation of transcription, DNA-dependent 4.03E-09 55
  0007155: cell adhesion 5.06E-08 90
  0007411: axon guidance 9.83E-08 24
KEGG Pathways    
  Pathway Hyp* Genes
  05200: Pathways in cancer 1.84E-05 33
  04010: MAPK signalling pathway 3.62E-05 31
  04144: Endocytosis 1.89E-04 19
  04510: Focal adhesion 2.34E-04 25
  04810: Regulation of actin cytoskeleton 4.11E-04 22
  04350: TGF-beta signalling pathway 8.67E-04 12
  04141: Protein processing in endoplasmic reticulum 2.19E-03 18
  04630: Jak-STAT signalling pathway 5.07E-03 15
  04310: Wnt signalling pathway 5.29E-03 14
  04520: Adherens junction 5.68E-03 10
Panther pathways    
  Pathway Hyp* Genes
  P00057: Wnt signalling pathway 6.66E-09 36
  P00012: Cadherin signalling pathway 8.93E-06 20
  P00018: EGF receptor signalling pathway 1.25E-04 18
  P00034: Integrin signalling pathway 4.11E-04 17
  P00021: FGF signalling pathway 8.83E-04 14
  P00047: PDGF signalling pathway 2.18E-03 13
  P00060: Ubiquitin proteasome pathway 2.67E-03 11
  P00048: PI3 kinase pathway 5.06E-03 8
  P00036: Interleukin signalling pathway 6.23E-03 11
  P04393: Ras pathway 7.82E-03 10
  1. The number of predicted target genes in the process or pathway is shown. Hyp*: corrected hypergeometric p-value.