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Table 4 Number of events for toxicities associated with the administration of taurolidine to dogs with osteosarcoma

From: Pharmacokinetic study and evaluation of the safety of taurolidine for dogs with osteosarcoma

Toxicity Grade I Circumstances Grade II Circumstances
Bone marrow     
  Neutropenia 7 1 when T combined with D 2 Both when T combined with C
6 when T combined with C
  Thrombocytopenia 2 1 when T alone 3 2 when T combined with D
1 when T combined with D
1 when T combined with C
Gastrointestinal     
  Anorexia 4 2 when T combined with D 5 3 when T combined with D
1 when T combined with C 2 when T combined with C
1 when T given by itself one week after C
  Diarrhea 3 2 when T combined with D 0  
1 when T combined with C
  1. T = taurolidine, D = doxorubicin, C = carboplatin.