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Figure 2 | Journal of Experimental & Clinical Cancer Research

Figure 2

From: Kaposi sarcoma associated herpesvirus (KSHV) induces AKT hyperphosphorylation, bortezomib-resistance and GLUT-1 plasma membrane exposure in THP-1 monocytic cell line

Figure 2

KSHV-mediated AKT hyperphosphorylation correlates with a reduction of Bortezomib cytotoxic effect. A) THP-1 mock and KSHV-infected cells were treated with bortezomib (Bz,10nM, for 48h) or AKT inhibitor LY294002 (Ly, 1μM) or combination of both (Bz, 10 nM plus Ly, 1μM). Cell death measurements were assayed by trypan-blue staining. The result is the mean ± SD of three independent experiments performed in duplicates. *p = 0.01. B) Western blot analysis of Cleaved-PARP of mock and THP-1-KSHV-infected cells untreated or treated with bortezomib (BZ), LY294002 (Ly) or both (Ly + BZ). β-actin is included as protein loading control.

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