Analysis | No. of studies | Homozygote (GG vs. TT) | Heterozygote (TG vs. TT) | Dominant model (GG + TG vs. TT) | Recessive model (GG vs. TG + TT) | ||||
---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P/P Q | OR (95% CI) | P/P Q | OR (95% CI) | P/P Q | OR (95% CI) | P/P Q | ||
Overall | 8 | 1.464 (1.246-1.721) | 0.000/0.175 | 1.073 (0.955-1.205) | 0.238/0.312 | 1.169 (1.048-1.304) | 0.005/0.759 | 1.726 (1.251-2.380) | 0.001/0.000 |
Ethnicity | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Caucasian | 6 | 1.453 (1.225-1.724) | 0.000/0.181 | 1.084 (0.960-1.223) | 0.192/0.521 | 1.173 (1.047-1.315) | 0.006/0.900 | 1.748 (1.161-2.632) | 0.007/0.000 |
Asian | 2 | 1.560 (0.943-2.581) | 0.083/0.542 | 0.855 (0.358-2.038) | 0.723/0.156 | 1.047 (0.531-2.064) | 0.894/0.113 | 0.981 (0.813-1.525) | 0.212/0.494 |
Study quality | Â | Â | Â | Â | Â | Â | Â | Â | Â |
High quality | 5 | 1.376 (1.157-1.637) | 0.000/0.569 | 1.120 (0.992-1.264) | 0.068/0.883 | 1.174 (1.047-1.316) | 0.006/0.929 | 1.495 (1.293-1.728) | 0.002/0.368 |
Low quality | 3 | 2.264 (1.421-3.607) | 0.001/0.191 | 0.748 (0.428-1.023) | 0.121/0.705 | 1.118 (0.766-1.631) | 0.563/0.195 | 3.124 (2.146-4.548) | 0.000/0.130 |
HWE in controls | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Yes | 7 | 1.473 (1.249-1.737) | 0.000/0.119 | 1.093 (0.971-1.230) | 0.141/0.601 | 1.184 (1.060-1.323) | 0.003/0.907 | 1.471 (1.267-1.707) | 0.000/0.000 |
No | 1 | 1.268 (0.549-2.928) | 0.579/— | 0.528 (0.254-1.100) | 0.088/— | 0.708 (0.353-1.421) | 0.332/— | 1.830 (0.974-3.830) | 0.067/— |