Table 2 Summary of gene function and chromosomal localization
Gene | Function | Chromosomal localization |
|---|---|---|
TIMP metallopeptidase inhibitor 3 (TIMP3) | Invasion and metastasis | 22q12.3 |
Adenomatous polyposis coli (APC) | WNT antagonist | 5q22 |
cyclin-dependent kinase inhibitor 2A (CDKN2A) | Cell-cycle control gene | 9p21 |
MutL homolog 1, colon cancer, nonpolyposis type 2 (MLH1) | DNA mismatch repair | 3p22.1 |
Ataxia telangiectasia mutated (ATM) | Cell-cycle control gene | 11q23 |
Retinoic acid receptor, beta (RARB) | Cell differentiation and proliferation | 3p24.2 |
Hypermethylated in Cancer 1(HIC1) | Putative tumor suppressor gene | 17p13.3 |
Checkpoint with forkhead and ring finger domains (CHFR) | Putative tumor suppressor gene | 12q24.33 |
breast cancer 1, early onset (BRCA1) | Maintenant of genomic stability | 17q21.31 |
Caspase 8, apoptosis-related cysteine peptidase (CASP8) | Apoptosis related gene | 2q33.2 |
Cyclin-dependent kinase inhibitor 1B (CDKN1B) | Cell-cycle control gene | 12p13.2 |
Phosphatase and tensin homolog (PTEN) | Cell-cycle regulation gene | 10q23.3 |
Breast cancer 2, early onset (BRCA2) | Maintenance of genomic stability | 13q12.3 |
CD44 molecule (Indian blood group) (CD44) | Cell-cell interaction mediator | 11p12 |
Ras association (RalGDS/AF-6) domain family member 1 (RASSF1) | Putative tumor suppressor gene | 3p21.3 |
Death-associated protein kinase1 (DAPK) | Apoptosis-related gene | 9q34.1 |
Von Hippel-Lindau tumor suppressor (VHL) | Putative tumor suppressor gene | 3p25 |
Estrogen receptor 1 (ESR1) | Cell differentiation and proliferation | 6q25.1 |
Tumor protein p73 (TP73) | Apoptotic response to DNA damage | 1p36.32 |
Fragile histidine triad gene (FHIT) | Putative tumor suppressor gene | 3p14.2 |
Cell adhesion molecule 1 (IGSF4 (CADM1)) | Cell adhesion related gene | 11q23 |
Cadherin 13, H-cadherin (heart) (CDH13) | Cell invasion | 16q23.3 |
Glutathione S-transferase pi 1 (GSTP1) | DNA damage repair gene | 11q13 |