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Table 3 Methylation frequencies of different genes in the overall series and in non recurrent or recurrent tumors

From: DNA Methylation profiles as predictors of recurrence in non muscle invasive bladder cancer: an MS-MLPA approach

  Frequency (%)
Gene Overall series (n = 74) Non recurrent tumors (n = 38) Recurrent tumors (n = 36) P value*
CD44 1 18 3 0.06
CASP8 1 3 0 1
MLH1 (locus 2) 1 3 0 1
PTEN 3 5 0 0.49
VHL 3 5 0 0.49
BRCA1 4 8 0 0.24
CHFR 4 5 3 1
ATM 5 8 3 0.62
BRCA2 5 8 3 0.62
CDKN1B 5 5 5 1
RARB 6 8 6 1
HIC1 9 16 0 0.03
FHIT 10 1 10 1
MLH1 (locus 1) 11 15 8 0.48
ESR1 12 16 6 0.26
TIMP3 13 18 8 0.31
TP73 14 19 8 0.19
CDKN2A 14 16 14 1
GSTP1 15 26 5 0.02
DAPK 17 24 8 0.11
IGSF4 (CADM1) 21 18 25 0.58
RASSF1 (locus 1) 23 29 14 0.16
APC 29 34 25 0.45
RASSF1 (locus2) 33 45 19 0.03
CDH13 50 53 47 0.81
  1. *Fisher’s exact test 2-tailed P value (difference between recurrent and non recurrent tumors). Significant genes are highlighted as bold data.