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Figure 1 | Journal of Experimental & Clinical Cancer Research

Figure 1

From: Regulation of microRNAs by epigenetics and their interplay involved in cancer

Figure 1

A model depicting the mechanisms of histone modification that repress miRNA expression. MYC or NF-κB, which interacts with transcription factor YY1 or Sp1 on miRNA promoter, is hypothesized to be the upstream regulator of miRNA silencing. Various histone modifying enzymes such as EZH2 and HDACs can be recruited to methylate and deacetylate histones. A positive feedback loop exists between MYC and EZH2: MYC stimulates EZH2 expression by reducing its negative regulators, miR-26a and miR-101; EZH2 can also increase the abundance of MYC by repressing miR-494.

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