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Figure 2 | Journal of Experimental & Clinical Cancer Research

Figure 2

From: IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer

Figure 2

JAK-dependent activation of STAT1 and STAT3 by IL-27 treatment. A549 cells were cultured in the presence of JAK inhibitor I (1-100 nM) for 1 hour prior to IL-27 (50 ng/mL) exposure for 24 hours. The activated and total amounts of STAT1 and STAT3 proteins were detected by Western blot. The densitometric measurements of total amounts of STAT1 and STAT3 were taken using Image J1.45o. The values above the figures represent relative density of the bands compared to control DMSO that was set to 1 after normalized to GAPDH.

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