TY - JOUR AU - Vasen, H. F. AU - Mecklin, J. P. AU - Khan, P. M. PY - 1991 DA - 1991// TI - The international collaborative group on hereditary non-polyposis colorectal cancer (ICG-HNPCC) JO - Dis Colon Rectum VL - 34 UR - https://doi.org/10.1007/BF02053699 DO - 10.1007/BF02053699 ID - Vasen1991 ER - TY - JOUR AU - Vasen, H. F. AU - Watson, P. AU - Mecklin, J. P. PY - 1999 DA - 1999// TI - New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, lynch syndrome) proposed by the international collaborative group on HNPCC JO - Gastroenterology VL - 116 UR - https://doi.org/10.1016/S0016-5085(99)70510-X DO - 10.1016/S0016-5085(99)70510-X ID - Vasen1999 ER - TY - JOUR AU - Lynch, H. T. AU - de la Chapelle, A. PY - 2003 DA - 2003// TI - Hereditary colorectal cancer JO - N Engl J Med VL - 348 UR - https://doi.org/10.1056/NEJMra012242 DO - 10.1056/NEJMra012242 ID - Lynch2003 ER - TY - JOUR AU - Jasperson, K. W. AU - Tuohy, T. M. AU - Neklason, D. W. PY - 2010 DA - 2010// TI - Hereditary and familial colon cancer JO - Gastroenterology VL - 138 UR - https://doi.org/10.1053/j.gastro.2010.01.054 DO - 10.1053/j.gastro.2010.01.054 ID - Jasperson2010 ER - TY - JOUR AU - Barrow, E. AU - Alduaij, W. AU - Robinson, L. PY - 2008 DA - 2008// TI - Colorectal cancer in HNPCC: cumulative lifetime incidence, survival and tumour distribution. A report of 121 families with proven mutations JO - Clin Genet VL - 74 UR - https://doi.org/10.1111/j.1399-0004.2008.01035.x DO - 10.1111/j.1399-0004.2008.01035.x ID - Barrow2008 ER - TY - JOUR AU - Vasen, H. F. AU - Abdirahman, M. AU - Brohet, R. PY - 2010 DA - 2010// TI - One to 2-year surveillance intervals reduce risk of colorectal cancer in families with lynch syndrome JO - Gastroenterology VL - 138 UR - https://doi.org/10.1053/j.gastro.2010.02.053 DO - 10.1053/j.gastro.2010.02.053 ID - Vasen2010 ER - TY - JOUR AU - Järvinen, H. J. AU - Renkonen-Sinisalo, L. AU - Aktán-Collán, K. PY - 2009 DA - 2009// TI - Ten years after mutation testing for lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members JO - J Clin Oncol VL - 27 UR - https://doi.org/10.1200/JCO.2009.23.7784 DO - 10.1200/JCO.2009.23.7784 ID - Järvinen2009 ER - TY - JOUR AU - Lynch, H. T. AU - Lynch, P. M. AU - Lanspa, S. J. PY - 2009 DA - 2009// TI - Review of the lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications JO - Clin Genet VL - 76 UR - https://doi.org/10.1111/j.1399-0004.2009.01230.x DO - 10.1111/j.1399-0004.2009.01230.x ID - Lynch2009 ER - TY - JOUR AU - Umar, A. AU - Boland, C. R. AU - Terdiman, J. P. PY - 2004 DA - 2004// TI - Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (lynch syndrome) and microsatellite instability JO - J Natl Cancer Inst VL - 96 UR - https://doi.org/10.1093/jnci/djh034 DO - 10.1093/jnci/djh034 ID - Umar2004 ER - TY - JOUR AU - Meyer, J. E. AU - Narang, T. AU - Schnoll-Sussman, F. H. PY - 2010 DA - 2010// TI - Increasing incidence of rectal cancer in patients aged younger than 40 years: an analysis of the surveillance, epidemiology, and end results database JO - Cancer VL - 116 UR - https://doi.org/10.1002/cncr.25432 DO - 10.1002/cncr.25432 ID - Meyer2010 ER - TY - JOUR AU - O’Connell, J. B. AU - Maggard, M. A. AU - Liu, J. H. PY - 2003 DA - 2003// TI - Rates of colon and rectal cancers are increasing in young adults JO - Am Surg VL - 69 ID - O’Connell2003 ER - TY - JOUR AU - Siegel, R. L. AU - Jemal, A. AU - Ward, E. M. PY - 2009 DA - 2009// TI - Increase incidence of colorectal cancer among young men and women in the United States JO - Cancer Epidemiol Biomatkers Prev VL - 18 UR - https://doi.org/10.1158/1055-9965.EPI-09-0186 DO - 10.1158/1055-9965.EPI-09-0186 ID - Siegel2009 ER - TY - JOUR AU - Chang, D. T. AU - Pai, R. K. AU - Rybicki, L. A. PY - 2012 DA - 2012// TI - Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features JO - Mod Pathol VL - 25 UR - https://doi.org/10.1038/modpathol.2012.61 DO - 10.1038/modpathol.2012.61 ID - Chang2012 ER - TY - JOUR AU - Mills, S. E. AU - Allen, M. S. PY - 1979 DA - 1979// TI - Colorectal carcinoma in the first three decades of life JO - Am J Surg Pathol VL - 3 UR - https://doi.org/10.1097/00000478-197910000-00006 DO - 10.1097/00000478-197910000-00006 ID - Mills1979 ER - TY - JOUR AU - Minardi, A. J. AU - Sittig, K. M. AU - Zibari, G. B. PY - 1998 DA - 1998// TI - Colorectal cancer in the young patient JO - Am Surg VL - 64 ID - Minardi1998 ER - TY - JOUR AU - Parramore, J. B. AU - Wei, J. P. AU - Yeh, K. A. PY - 1998 DA - 1998// TI - Colorectal cancer in patients under forty: presentation and outcome JO - Am Surg VL - 64 ID - Parramore1998 ER - TY - JOUR AU - Smith, C. AU - Butler, J. A. PY - 1989 DA - 1989// TI - Colorectal cancer in patients younger than 40 years of age JO - Dis Colon Rectum VL - 32 UR - https://doi.org/10.1007/BF02554552 DO - 10.1007/BF02554552 ID - Smith1989 ER - TY - JOUR AU - Yantiss, R. K. AU - Goodarzi, M. AU - Zhou, X. K. PY - 2009 DA - 2009// TI - Clinical, pathologic, and molecular features of early-onset colorectal carcinoma JO - Am J Surg Pathol VL - 33 UR - https://doi.org/10.1097/PAS.0b013e31818afd6b DO - 10.1097/PAS.0b013e31818afd6b ID - Yantiss2009 ER - TY - JOUR AU - Antelo, M. AU - Balaguer, F. AU - Shia, J. PY - 2012 DA - 2012// TI - A high degree of LINE-1 hypomethylation is a unique feature of early-onset colorectal cancer JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0045357 DO - 10.1371/journal.pone.0045357 ID - Antelo2012 ER - TY - JOUR AU - Jasperson, K. W. AU - Vu, T. M. AU - Schwab, A. L. PY - 2010 DA - 2010// TI - Evaluating lynch syndrome in very early onset colorectal cancer probands without apparent polyposis JO - Fam Cancer VL - 9 UR - https://doi.org/10.1007/s10689-009-9290-4 DO - 10.1007/s10689-009-9290-4 ID - Jasperson2010 ER - TY - JOUR AU - Southey, M. C. AU - Jenkins, M. A. AU - Mead, L. PY - 2005 DA - 2005// TI - Use of molecular tumor characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer JO - Clin Oncol VL - 23 UR - https://doi.org/10.1200/JCO.2005.04.671 DO - 10.1200/JCO.2005.04.671 ID - Southey2005 ER - TY - JOUR AU - Jenkins, M. A. AU - Baglietto, L. AU - Dite, G. S. PY - 2002 DA - 2002// TI - After hMSH2 and hMLH1–what next? Analysis of three-generational, population-based, early-onset colorectal cancer families JO - Int J Cancer VL - 102 UR - https://doi.org/10.1002/ijc.10670 DO - 10.1002/ijc.10670 ID - Jenkins2002 ER - TY - JOUR AU - Steinhagen, E. AU - Shia, J. AU - Markowitz, A. J. PY - 2012 DA - 2012// TI - Systematic immunohistochemistry screening for lynch syndrome in early age-of-onset colorectal cancer patients undergoing surgical resection JO - J Am Coll Surg VL - 214 UR - https://doi.org/10.1016/j.jamcollsurg.2011.10.004 DO - 10.1016/j.jamcollsurg.2011.10.004 ID - Steinhagen2012 ER - TY - JOUR AU - Limburg, P. J. AU - Harmsen, W. S. AU - Chen, H. H. PY - 2011 DA - 2011// TI - Prevalence of alterations in DNA mismatch repair genes in patients with young-onset colorectal cancer JO - Clin Gastroenterol Hepatol VL - 9 UR - https://doi.org/10.1016/j.cgh.2010.10.021 DO - 10.1016/j.cgh.2010.10.021 ID - Limburg2011 ER - TY - JOUR AU - Farrington, S. M. AU - Lin-Goerke, J. AU - Ling, J. AU - Wang, Y. AU - Burczak, J. D. AU - Robbins, D. J. AU - Dunlop, M. G. PY - 1998 DA - 1998// TI - Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls JO - Am J Hum Genet VL - 63 UR - https://doi.org/10.1086/301996 DO - 10.1086/301996 ID - Farrington1998 ER - TY - JOUR AU - Bonnet, D. AU - Selves, J. AU - Toulas, C. PY - 2012 DA - 2012// TI - Simplified identification of lynch syndrome: a prospective, multicenter study JO - Dig Liver Dis VL - 44 UR - https://doi.org/10.1016/j.dld.2011.12.020 DO - 10.1016/j.dld.2011.12.020 ID - Bonnet2012 ER - TY - JOUR AU - Perea, J. AU - Alvaro, E. AU - Rodríguez, Y. PY - 2010 DA - 2010// TI - Approach to early-onset colorectal cancer: clinicopathological, familial, molecular and immunohistochemical characteristics JO - World J Gastroenterol VL - 16 UR - https://doi.org/10.3748/wjg.v16.i29.3697 DO - 10.3748/wjg.v16.i29.3697 ID - Perea2010 ER - TY - JOUR AU - Giraldez, M. D. AU - Balaguer, F. AU - Bujanda, L. PY - 2010 DA - 2010// TI - MSH6 and MUTYH deficiency is a frequent event in early-onset colorectal cancer JO - Clin Cancer Res VL - 16 UR - https://doi.org/10.1158/1078-0432.CCR-10-1491 DO - 10.1158/1078-0432.CCR-10-1491 ID - Giraldez2010 ER - TY - JOUR AU - Goel, A. AU - Nagasaka, T. AU - Spiegel, J. PY - 2010 DA - 2010// TI - Low frequency of lynch syndrome among young patients with non-familial colorectal cancer JO - Clin Gastroenterol Hepatol VL - 8 UR - https://doi.org/10.1016/j.cgh.2010.06.030 DO - 10.1016/j.cgh.2010.06.030 ID - Goel2010 ER - TY - JOUR AU - Gryfe, R. AU - Kim, H. AU - Hsieh, E. T. PY - 2000 DA - 2000// TI - Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer JO - N Engl J Med VL - 342 UR - https://doi.org/10.1056/NEJM200001133420201 DO - 10.1056/NEJM200001133420201 ID - Gryfe2000 ER - TY - JOUR AU - Losi, L. AU - Di Gregorio, C. AU - Pedroni, M. PY - 2005 DA - 2005// TI - Molecular genetic alterations and clinical features in early-onset colorectal carcinomas and their role for the recognition of hereditary cancer syndromes JO - Am J Gastroenterol VL - 100 UR - https://doi.org/10.1111/j.1572-0241.2005.00223.x DO - 10.1111/j.1572-0241.2005.00223.x ID - Losi2005 ER - TY - JOUR AU - Pucciarelli, S. AU - Agostini, M. AU - Viel, A. PY - 2003 DA - 2003// TI - Early-age-at-onset colorectal cancer and microsatellite instability as markers of hereditary nonpolyposis colorectal cancer JO - Dis Colon Rectum VL - 46 UR - https://doi.org/10.1007/s10350-004-6546-9 DO - 10.1007/s10350-004-6546-9 ID - Pucciarelli2003 ER - TY - JOUR AU - Hampel, H. AU - Frankel, W. L. AU - Martin, E. PY - 2005 DA - 2005// TI - Screening for the lynch syndrome (hereditary nonpolyposis colorectal cancer) JO - N Engl J Med VL - 352 UR - https://doi.org/10.1056/NEJMoa043146 DO - 10.1056/NEJMoa043146 ID - Hampel2005 ER - TY - JOUR AU - Boland, C. R. AU - Shike, M. PY - 2010 DA - 2010// TI - Report from the Jerusalem workshop on lynch syndrome-hereditary nonpolyposis colorectal cancer JO - Gastroenterology VL - 138 UR - https://doi.org/10.1053/j.gastro.2010.04.024 DO - 10.1053/j.gastro.2010.04.024 ID - Boland2010 ER - TY - STD TI - National Comprehensive Cancer Network Guidelines (NCCN) version 2: 2013, Online at http://www.nccn.org UR - http://www.nccn.org ID - ref35 ER - TY - JOUR AU - Nygren, A. O. H. AU - Ameziane, N. AU - Duarte, H. M. B. PY - 2005 DA - 2005// TI - Methylation-specific MLPA (MS-MLPA): simultaneous detection of CpG methylation and copy number changes of up to 40 sequences JO - Nucleic Acids Res VL - 33 UR - https://doi.org/10.1093/nar/gni127 DO - 10.1093/nar/gni127 ID - Nygren2005 ER - TY - JOUR AU - Dufort, S. AU - Richard, M. J. AU - Lantuejoul, S. PY - 2011 DA - 2011// TI - Pyrosequencing, a method approved to detect the two major EGFR mutations for anti EGFR therapy in NSCLC JO - J Exp Clin Cancer Res VL - 30 UR - https://doi.org/10.1186/1756-9966-30-57 DO - 10.1186/1756-9966-30-57 ID - Dufort2011 ER - TY - JOUR AU - Campbell, P. T. AU - Curtin, K. AU - Ulrich, C. M. PY - 2009 DA - 2009// TI - Mismatch repair polymorphisms and risk of colon cancer, tumour microsatellite instability and interactions with lifestyle factors JO - Gut VL - 58 UR - https://doi.org/10.1136/gut.2007.144220 DO - 10.1136/gut.2007.144220 ID - Campbell2009 ER - TY - JOUR AU - Niessen, R. C. AU - Berends, M. J. AU - Wu, Y. PY - 2006 DA - 2006// TI - Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary non-polyposis colorectal cancer JO - Gut VL - 55 UR - https://doi.org/10.1136/gut.2005.090159 DO - 10.1136/gut.2005.090159 ID - Niessen2006 ER - TY - JOUR AU - Wright, D. M. AU - Arnold, J. L. AU - Parry, B. PY - 2011 DA - 2011// TI - Immunohistochemistry to detect hereditary nonpolyposis colorectal cancer in young patients: the 7-year Auckland experience JO - Dis Colon Rectum VL - 54 UR - https://doi.org/10.1007/DCR.0b013e31820e3265 DO - 10.1007/DCR.0b013e31820e3265 ID - Wright2011 ER - TY - JOUR AU - Ahnen, D. J. PY - 2011 DA - 2011// TI - The American college of gastroenterology Emily couric lecture — the adenoma – carcinoma sequence revisited: has the Era of genetic tailoring finally arrived? JO - Am J Gastroenterol VL - 106 UR - https://doi.org/10.1038/ajg.2010.423 DO - 10.1038/ajg.2010.423 ID - Ahnen2011 ER - TY - JOUR AU - Berndt, S. I. AU - Platz, E. A. AU - Fallin, M. D. PY - 2007 DA - 2007// TI - Mismatch repair polymorphisms and the risk of colorectal cancer JO - Int J Cancer VL - 120 UR - https://doi.org/10.1002/ijc.22510 DO - 10.1002/ijc.22510 ID - Berndt2007 ER - TY - JOUR AU - Bussolati, G. AU - Leonardo, E. PY - 2008 DA - 2008// TI - Technical pitfalls potentially affecting diagnoses in immunohistochemistry JO - J Clin Pathol VL - 61 UR - https://doi.org/10.1136/jcp.2007.047720 DO - 10.1136/jcp.2007.047720 ID - Bussolati2008 ER - TY - JOUR AU - Hassen, S. AU - Boman, B. M. AU - Ali, N. PY - 2011 DA - 2011// TI - Detection of DNA mismatch repair proteins in fresh human blood lymphocytes – towards a novel method for hereditary non polyposis colorectal cancer (lynch syndrome) screening JO - J Exp Clin Cancer Res VL - 30 UR - https://doi.org/10.1186/1756-9966-30-100 DO - 10.1186/1756-9966-30-100 ID - Hassen2011 ER -