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Figure 5 | Journal of Experimental & Clinical Cancer Research

Figure 5

From: Inhibition of Aurora B by CCT137690 sensitizes colorectal cells to radiotherapy

Figure 5

The mechanism underlying the synergic action between CCT137690 and radiation. A and B, relative expression of the indicated genes in SW620 cells treated by control or siRNA of the indicated target, mean ± SD, (n = 3). C, surviving fractions of siRNA transfected cells (from A, B) with or without radiation. D, Western blot analysis of Aurora B, Ser10-phosphorated Histone H3, Histone H3, survivin and GAPDH in cells with indicated treatments (IR means 1 Gy, drug = 100 nM). E, the protein levels of survivin and GAPDH in SW48 and SW620 cells. F, protein levels of survivin and GAPDH in SW48 cells with or without survivin over-expression. G, the surviving fractions of SW48 cells with or without survivin over-expression upon radiation. H, the protein levels of survivin and GAPDH in cells with or without survivin over-expression under indicated treatments (IR =1 Gy, drug = 100 nM). I, the surviving fractions of cells described in H, mean ± SD, (n = 3).

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