Journal of Experimental & Clinical Cancer Research

Table 2 Association between miR-34a promoter methylation and clinicopathologic features in ESCC patients

From: Inactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma

CpG unit	CpG site	Clinical characteristic (Z/P)
CpG unit	CpG site	Gender^¶		Age^¶		Tumor location^¶		Differentiation^#		Lymphatic metastasis^¶		TNM stage^¶
Unit1	CpG_1.2	−1.396	0.163	−0.364	0.716	−1.227	0.220	0.334	0.846	−0.628	0.530	−0.838	0.402
Unit2	CpG_3	−1.075	0.282	−0.259	0.796	−1.592	0.057	5.813	0.055	−0.397	0.691	−1.440	0.150
Unit3	CpG_4	−1.558	0.119	−0.457	0.648	−1.359	0.174	2.136	0.344	−0.708	0.479	−1.019	0.308
Unit4	CpG_5	−0.039	0.969	−0.528	0.598	−0.607	0.544	1.901	0.386	−2.223	0.026*	−0.625	0.532
Unit5	CpG_6	−0.168	0.866	−0.330	0.741	−1.057	0.291	2.992	0.224	−1.551	0.121	−0.732	0.464
Unit7	CpG_8.9	−0.450	0.653	−0.076	0.939	−0.093	0.926	2.221	0.896	−2.299	0.022*	−2.188	0.029*
Unit9	CpG_14.15.16	−1.429	0.153	−0.360	0.719	−0.891	0.373	1.940	0.379	−0.029	0.976	−0.092	0.926
Unit10	CpG_17.18	−0.086	0.931	−0.770	0.441	−0.160	0.873	2.183	0.336	−0.612	0.541	−4.70	0.638
Unit11	CpG_19	−0.211	0.833	−0.459	0.646	−0.397	0.691	0.225	0.893	−0.328	0.743	−0.967	0.334
Unit12	CpG_20	−0.382	0.702	−0.692	0.489	−0.559	0.576	0.137	0.934	−0.328	0.743	−1.077	0.282
Unit15	CpG_23	−0.128	0.898	−0.460	0.646	−1.696	0.090	0.735	0.692	−0.711	0.477	−0.174	0.862

Note: ^¶Mann–Whitney U test (two-sided); ^#Kruskal-Wallis H test (two-sided); *P < 0.05, bold face representing significant data.

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