Table 1 Detectable metastatic disease and clinical characteristics of breast cancer patients

Age (years)

≥ 35

3106

3064 (98.6)

42 (1.4)

1.000

3095 (99.6)

11 (0.4)

0.241

3100 (99.8)

6 (0.2)

0.481

< 35

305

301 (98.7)

4 (1.3)

302 (99.0)

3 (1.0)

304 (99.7)

1 (0.3)

Histological differentiation

I

411

406 (98.8)

5 (1.2)

0.649

409 (99.5)

2 (0.5)

0.95

410 (99.8)

1 (0.2)

0.839

II

2561

2528 (98.7)

33 (1.3)

2551 (99.6)

10 (0.4)

2556 (99.8)

5 (0.2)

III

439

431 (98.2)

8 (1.8)

437 (99.5)

2 (0.5)

438 (99.8)

1 (0.2)

cT stage

cT1

1314

1304 (99.2)

10 (0.8)

0.000

1312 (99.8)

2 (0.2)

0.003

1313 (99.9)

1 (0.1)

0.04

cT2

1859

1833 (98.6)

26 (1.4)

1851 (98.6)

8 (1.4)

1855 (99.8)

4 (0.2)

cT3

198

192 (97.0)

6 (3.0)

196 (98.9)

2 (1.0)

197 (99.5)

1 (0.5)

cT4

40

36 (90.0)

4 (10.0)

38 (95.0)

2 (5.0)

39 (97.5)

1 (2.5)

cN stage

cN0

1592

1588 (99.7)

4 (0.3)

0.000

1592 (100.0)

0 (0.0)

0.000

1591 (99.9)

1 (0.0)

0.018

cN1

1044

1028 (98.5)

16 (1.5)

1042 (99.8)

2 (0.2)

1043 (99.9)

1 (0.2)

cN2

462

449 (97.2)

13 (2.8)

456 (98.7)

6 (1.3)

459 (99.4)

3 (1.3)

cN3

313

300 (95.8)

13 (4.2)

307 (98.1)

6 (1.9)

311 (99.4)

2 (1.9)

ER status

(-)

1317

1301 (98.8)

16 (1.2)

0.591

1307 (99.2)

10 (0.8)

0.011

1312 (99.6)

5 (0.4)

0.162

(+)

2094

2064 (98.6)

30 (1.4)

2090 (99.8)

4 (0.2)

2092 (99.9)

2 (0.1)

PR status

(-)

1131

1110 (98.4)

21 (1.6)

0.07

1122 (99.2)

9 (0.8)

0.028

1126 (99.6)

5 (0.8)

0.08

(+)

2280

2255 (98.8)

25 (1.2)

2275 (99.8)

5 (0.2)

2278 (99.9)

2 (0.1)

HER2 status

(-)

2640

2614 (99.0)

26 (1.0)

0.001

2634 (99.8)

6 (0.2)

0.006

2634 (99.8)

6 (0.2)

0.941

(+)

771

751 (97.4)

20 (2.6)

763 (99.0)

8 (0.1)

770 (99.9)

1 (0.1)

Ki67 index

≤ 14%

1331

1315 (98.8)

16 (0.2)

0.553

1325 (99.5)

6 (0.5)

0.768

1329 (98.8)

2 (1.2)

0.857

> 14%

2080

2050 (98.6)

30 (0.4)

2072 (99.6)

8 (0.4)

2075 (98.6)

5 (1.4)