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Table 1 Detectable metastatic disease and clinical characteristics of breast cancer patients

From: Baseline staging tests based on molecular subtype is necessary for newly diagnosed breast cancer

   Bone metastasis, n (%) Liver metastasis, n (%) Lung metastasis, n (%)
Variables No. of patients (-) (+) P (χ2) (-) (+) P (χ2) (-) (+) P (χ2)
Age (years)          
≥ 35 3106 3064 (98.6) 42 (1.4) 1.000 3095 (99.6) 11 (0.4) 0.241 3100 (99.8) 6 (0.2) 0.481
< 35 305 301 (98.7) 4 (1.3)   302 (99.0) 3 (1.0)   304 (99.7) 1 (0.3)  
Histological differentiation          
I 411 406 (98.8) 5 (1.2) 0.649 409 (99.5) 2 (0.5) 0.95 410 (99.8) 1 (0.2) 0.839
II 2561 2528 (98.7) 33 (1.3)   2551 (99.6) 10 (0.4)   2556 (99.8) 5 (0.2)  
III 439 431 (98.2) 8 (1.8)   437 (99.5) 2 (0.5)   438 (99.8) 1 (0.2)  
cT stage          
cT1 1314 1304 (99.2) 10 (0.8) 0.000 1312 (99.8) 2 (0.2) 0.003 1313 (99.9) 1 (0.1) 0.04
cT2 1859 1833 (98.6) 26 (1.4)   1851 (98.6) 8 (1.4)   1855 (99.8) 4 (0.2)  
cT3 198 192 (97.0) 6 (3.0)   196 (98.9) 2 (1.0)   197 (99.5) 1 (0.5)  
cT4 40 36 (90.0) 4 (10.0)   38 (95.0) 2 (5.0)   39 (97.5) 1 (2.5)  
cN stage          
cN0 1592 1588 (99.7) 4 (0.3) 0.000 1592 (100.0) 0 (0.0) 0.000 1591 (99.9) 1 (0.0) 0.018
cN1 1044 1028 (98.5) 16 (1.5)   1042 (99.8) 2 (0.2)   1043 (99.9) 1 (0.2)  
cN2 462 449 (97.2) 13 (2.8)   456 (98.7) 6 (1.3)   459 (99.4) 3 (1.3)  
cN3 313 300 (95.8) 13 (4.2)   307 (98.1) 6 (1.9)   311 (99.4) 2 (1.9)  
ER status          
(-) 1317 1301 (98.8) 16 (1.2) 0.591 1307 (99.2) 10 (0.8) 0.011 1312 (99.6) 5 (0.4) 0.162
(+) 2094 2064 (98.6) 30 (1.4)   2090 (99.8) 4 (0.2)   2092 (99.9) 2 (0.1)  
PR status          
(-) 1131 1110 (98.4) 21 (1.6) 0.07 1122 (99.2) 9 (0.8) 0.028 1126 (99.6) 5 (0.8) 0.08
(+) 2280 2255 (98.8) 25 (1.2)   2275 (99.8) 5 (0.2)   2278 (99.9) 2 (0.1)  
HER2 status          
(-) 2640 2614 (99.0) 26 (1.0) 0.001 2634 (99.8) 6 (0.2) 0.006 2634 (99.8) 6 (0.2) 0.941
(+) 771 751 (97.4) 20 (2.6)   763 (99.0) 8 (0.1)   770 (99.9) 1 (0.1)  
Ki67 index          
≤ 14% 1331 1315 (98.8) 16 (0.2) 0.553 1325 (99.5) 6 (0.5) 0.768 1329 (98.8) 2 (1.2) 0.857
> 14% 2080 2050 (98.6) 30 (0.4)   2072 (99.6) 8 (0.4)   2075 (98.6) 5 (1.4)